γ-H2AX Kinetics as a Novel Approach to High Content Screening for Small Molecule Radiosensitizers

Shibo Fu; Ying Yang; Das Tirtha; Yun Yen; Bing-sen Zhou; Ming-Ming Zhou; Michael Ohlmeyer; Eric C. Ko; Ross Cagan; Barry S. Rosenstein; Shu-hsia Chen; Johnny Kao

doi:10.1371/journal.pone.0038465

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Open Access

Peer-reviewed

Research Article

γ-H2AX Kinetics as a Novel Approach to High Content Screening for Small Molecule Radiosensitizers

Shibo Fu,

Affiliations Department of Radiation Oncology, Mount Sinai School of Medicine, New York, New York, United States of America, Department of Radiation Biology, Jilin University School of Public Health, Changchun, China
⨯
Ying Yang,

Affiliation Department of Dermatology, Columbia University, New York, New York, United States of America
⨯
Das Tirtha,

Affiliation Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, New York, United States of America
⨯
Yun Yen,

Affiliation Department of Medical Oncology and Therapeutic Research, City of Hope National Medical Center, Duarte, California, United States of America
⨯
Bing-sen Zhou,

Affiliation Department of Medical Oncology and Therapeutic Research, City of Hope National Medical Center, Duarte, California, United States of America
⨯
Ming-Ming Zhou,

Affiliation Department of Structural and Chemical Biology, Mount Sinai School of Medicine, New York, New York, United States of America
⨯
Michael Ohlmeyer,

Affiliation Department of Structural and Chemical Biology, Mount Sinai School of Medicine, New York, New York, United States of America
⨯
Eric C. Ko,

Affiliation Department of Radiation Oncology, Mount Sinai School of Medicine, New York, New York, United States of America
⨯
Ross Cagan,

Affiliation Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, New York, United States of America
⨯
Barry S. Rosenstein,

Affiliation Department of Radiation Oncology, Mount Sinai School of Medicine, New York, New York, United States of America
⨯
Shu-hsia Chen,

Affiliation Department of Oncological Sciences, Mount Sinai School of Medicine, New York, New York, United States of America
⨯
Johnny Kao

* E-mail: Johnny.kao@chsli.org

Affiliations Department of Radiation Oncology, Mount Sinai School of Medicine, New York, New York, United States of America, Department of Radiation Oncology, Good Samaritan Hospital Medical Center, West Islip, New York, United States of America
⨯

γ-H2AX Kinetics as a Novel Approach to High Content Screening for Small Molecule Radiosensitizers

Shibo Fu,
Ying Yang,
Das Tirtha,
Yun Yen,
Bing-sen Zhou,
Ming-Ming Zhou,
Michael Ohlmeyer,
Eric C. Ko,
Ross Cagan,
Barry S. Rosenstein

Published: June 29, 2012
https://doi.org/10.1371/journal.pone.0038465

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