A2A Adenosine Receptor Antagonism Enhances Synaptic and Motor Effects of Cocaine via CB1 Cannabinoid Receptor Activation

Alessandro Tozzi; Antonio de Iure; Valentina Marsili; Rosaria Romano; Michela Tantucci; Massimiliano Di Filippo; Cinzia Costa; Francesco Napolitano; Nicola Biagio Mercuri; Franco Borsini; Carmen Giampà; Francesca Romana Fusco; Barbara Picconi; Alessandro Usiello; Paolo Calabresi

doi:10.1371/journal.pone.0038312

Loading metrics

Open Access

Peer-reviewed

Research Article

A2A Adenosine Receptor Antagonism Enhances Synaptic and Motor Effects of Cocaine via CB1 Cannabinoid Receptor Activation

Alessandro Tozzi,

Affiliations Clinica Neurologica, Università di Perugia, Ospedale S. Maria della Misericordia, Perugia, Italy, Fondazione Santa Lucia - IRCCS, Rome, Italy
⨯
Antonio de Iure,

Affiliations Clinica Neurologica, Università di Perugia, Ospedale S. Maria della Misericordia, Perugia, Italy, Fondazione Santa Lucia - IRCCS, Rome, Italy
⨯
Valentina Marsili,

Affiliation CEINGE - Biotecnologie Avanzate, Naples, Italy
⨯
Rosaria Romano,

Affiliation CEINGE - Biotecnologie Avanzate, Naples, Italy
⨯
Michela Tantucci,

Affiliations Clinica Neurologica, Università di Perugia, Ospedale S. Maria della Misericordia, Perugia, Italy, Fondazione Santa Lucia - IRCCS, Rome, Italy
⨯
Massimiliano Di Filippo,

Affiliation Clinica Neurologica, Università di Perugia, Ospedale S. Maria della Misericordia, Perugia, Italy
⨯
Cinzia Costa,

Affiliation Clinica Neurologica, Università di Perugia, Ospedale S. Maria della Misericordia, Perugia, Italy
⨯
Francesco Napolitano,

Affiliation CEINGE - Biotecnologie Avanzate, Naples, Italy
⨯
Nicola Biagio Mercuri,

Affiliation Fondazione Santa Lucia - IRCCS, Rome, Italy
⨯
Franco Borsini,

Affiliation Sigma - tau Industrie Riunite, Pomezia, Italy
⨯
Carmen Giampà,

Affiliation Fondazione Santa Lucia - IRCCS, Rome, Italy
⨯
Francesca Romana Fusco,

Affiliation Fondazione Santa Lucia - IRCCS, Rome, Italy
⨯
Barbara Picconi,

Affiliation Fondazione Santa Lucia - IRCCS, Rome, Italy
⨯
Alessandro Usiello,

Affiliations CEINGE - Biotecnologie Avanzate, Naples, Italy, Second University of Naples (SUN), Naples, Italy
⨯
Paolo Calabresi

* E-mail: calabre@unipg.it

Affiliations Clinica Neurologica, Università di Perugia, Ospedale S. Maria della Misericordia, Perugia, Italy, Fondazione Santa Lucia - IRCCS, Rome, Italy
⨯

A2A Adenosine Receptor Antagonism Enhances Synaptic and Motor Effects of Cocaine via CB1 Cannabinoid Receptor Activation

Alessandro Tozzi,
Antonio de Iure,
Valentina Marsili,
Rosaria Romano,
Michela Tantucci,
Massimiliano Di Filippo,
Cinzia Costa,
Francesco Napolitano,
Nicola Biagio Mercuri,
Franco Borsini

Published: June 8, 2012
https://doi.org/10.1371/journal.pone.0038312

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Cocaine
Is the Subject Area "Cocaine" applicable to this article?

Thanks for your feedback.
Interneurons
Is the Subject Area "Interneurons" applicable to this article?

Thanks for your feedback.
Cholinergics
Is the Subject Area "Cholinergics" applicable to this article?

Thanks for your feedback.
Neurotransmission
Is the Subject Area "Neurotransmission" applicable to this article?

Thanks for your feedback.
Electrophysiology
Is the Subject Area "Electrophysiology" applicable to this article?

Thanks for your feedback.
Biological locomotion
Is the Subject Area "Biological locomotion" applicable to this article?

Thanks for your feedback.
Neurons
Is the Subject Area "Neurons" applicable to this article?

Thanks for your feedback.
Excitatory postsynaptic potentials
Is the Subject Area "Excitatory postsynaptic potentials" applicable to this article?

Thanks for your feedback.