Transcriptome Kinetics of Circulating Neutrophils during Human Experimental Endotoxemia

Stan de Kleijn; Matthijs Kox; Iziah Edwin Sama; Janesh Pillay; Angela van Diepen; Martijn A. Huijnen; Johannes G. van der Hoeven; Gerben Ferwerda; Peter W. M. Hermans; Peter Pickkers

doi:10.1371/journal.pone.0038255

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Open Access

Peer-reviewed

Research Article

Transcriptome Kinetics of Circulating Neutrophils during Human Experimental Endotoxemia

Stan de Kleijn,

Affiliation Laboratory of Pediatric Infectious Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
⨯
Matthijs Kox,

Affiliations Intensive Care Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, Anesthesiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
⨯
Iziah Edwin Sama,

Affiliation Centre for Molecular and Biomolecular Informatics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
⨯
Janesh Pillay,

Affiliation Department of Respiratory Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
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Angela van Diepen,

Affiliations Laboratory of Pediatric Infectious Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, Parasitology, Leiden University Medical Center, Leiden, The Netherlands
⨯
Martijn A. Huijnen,

Affiliation Centre for Molecular and Biomolecular Informatics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
⨯
Johannes G. van der Hoeven,

Affiliation Intensive Care Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
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Gerben Ferwerda ,

* E-mail: J.Ferwerda@cukz.umcn.nl

Affiliation Laboratory of Pediatric Infectious Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
⨯
Peter W. M. Hermans,

Affiliation Laboratory of Pediatric Infectious Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
⨯
Peter Pickkers

Affiliation Intensive Care Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
⨯

Transcriptome Kinetics of Circulating Neutrophils during Human Experimental Endotoxemia

Stan de Kleijn,
Matthijs Kox,
Iziah Edwin Sama,
Janesh Pillay,
Angela van Diepen,
Martijn A. Huijnen,
Johannes G. van der Hoeven,
Gerben Ferwerda,
Peter W. M. Hermans,
Peter Pickkers

Published: June 5, 2012
https://doi.org/10.1371/journal.pone.0038255

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Neutrophils
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Inflammation
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Gene expression
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Protein interaction networks
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Protein-protein interactions
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Transcriptome analysis
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