Phase I Study of Cetuximab, Irinotecan, and Vandetanib (ZD6474) as Therapy for Patients with Previously Treated Metastastic Colorectal Cancer

Jeffrey A. Meyerhardt; Marek Ancukiewicz; Thomas A. Abrams; Deborah Schrag; Peter C. Enzinger; Jennifer A. Chan; Matthew H. Kulke; Brian M. Wolpin; Michael Goldstein; Lawrence Blaszkowsky; Andrew X. Zhu; Meaghan Elliott; Eileen Regan; Rakesh K. Jain; Dan G. Duda

doi:10.1371/journal.pone.0038231

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Open Access

Peer-reviewed

Research Article

Phase I Study of Cetuximab, Irinotecan, and Vandetanib (ZD6474) as Therapy for Patients with Previously Treated Metastastic Colorectal Cancer

Jeffrey A. Meyerhardt ,

* E-mail: jmeyerhardt@partners.org

Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Marek Ancukiewicz,

Affiliation Steele Laboratory of Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Thomas A. Abrams,

Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Deborah Schrag,

Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Peter C. Enzinger,

Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Jennifer A. Chan,

Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Matthew H. Kulke,

Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Brian M. Wolpin,

Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Michael Goldstein,

Affiliation Beth-Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
⨯
Lawrence Blaszkowsky,

Affiliation Division of Medical Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Andrew X. Zhu,

Affiliation Division of Medical Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Meaghan Elliott,

Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Eileen Regan,

Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Rakesh K. Jain,

Affiliation Steele Laboratory of Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Dan G. Duda

Affiliation Steele Laboratory of Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯

Phase I Study of Cetuximab, Irinotecan, and Vandetanib (ZD6474) as Therapy for Patients with Previously Treated Metastastic Colorectal Cancer

Jeffrey A. Meyerhardt,
Marek Ancukiewicz,
Thomas A. Abrams,
Deborah Schrag,
Peter C. Enzinger,
Jennifer A. Chan,
Matthew H. Kulke,
Brian M. Wolpin,
Michael Goldstein,
Lawrence Blaszkowsky

Published: June 12, 2012
https://doi.org/10.1371/journal.pone.0038231

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