Noninvasive Prenatal Diagnosis of Fetal Trisomy 21 by Allelic Ratio Analysis Using Targeted Massively Parallel Sequencing of Maternal Plasma DNA

Gary J. W. Liao; K. C. Allen Chan; Peiyong Jiang; Hao Sun; Tak Y. Leung; Rossa W. K. Chiu; Y. M. Dennis Lo

doi:10.1371/journal.pone.0038154

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Peer-reviewed

Research Article

Noninvasive Prenatal Diagnosis of Fetal Trisomy 21 by Allelic Ratio Analysis Using Targeted Massively Parallel Sequencing of Maternal Plasma DNA

Gary J. W. Liao,

Affiliations Centre for Research into Circulating Fetal Nucleic Acids, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China, Department of Chemical Pathology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
⨯
K. C. Allen Chan,

Affiliations Centre for Research into Circulating Fetal Nucleic Acids, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China, Department of Chemical Pathology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
⨯
Peiyong Jiang,

Affiliations Centre for Research into Circulating Fetal Nucleic Acids, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China, Department of Chemical Pathology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
⨯
Hao Sun,

Affiliations Centre for Research into Circulating Fetal Nucleic Acids, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China, Department of Chemical Pathology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
⨯
Tak Y. Leung,

Affiliation Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
⨯
Rossa W. K. Chiu,

Affiliations Centre for Research into Circulating Fetal Nucleic Acids, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China, Department of Chemical Pathology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
⨯
Y. M. Dennis Lo

* E-mail: loym@cuhk.edu.hk

Affiliations Centre for Research into Circulating Fetal Nucleic Acids, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China, Department of Chemical Pathology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
⨯

Noninvasive Prenatal Diagnosis of Fetal Trisomy 21 by Allelic Ratio Analysis Using Targeted Massively Parallel Sequencing of Maternal Plasma DNA

Gary J. W. Liao,
K. C. Allen Chan,
Peiyong Jiang,
Hao Sun,
Tak Y. Leung,
Rossa W. K. Chiu,
Y. M. Dennis Lo

Published: May 29, 2012
https://doi.org/10.1371/journal.pone.0038154

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Single nucleotide polymorphisms
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Genetic loci
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Blood plasma
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DNA sequencing
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Computer modeling
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Genomics
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Nucleotide sequencing
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Variant genotypes
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