Tumor Necrosis Factor α Inhibits Expression of the Iron Regulating Hormone Hepcidin in Murine Models of Innate Colitis

Nanda Kumar N. Shanmugam; Shiri Ellenbogen; Estela Trebicka; Lijian Wang; Subhankar Mukhopadhyay; Adam Lacy-Hulbert; Carey Ann Gallini; Wendy S. Garrett; Bobby J. Cherayil

doi:10.1371/journal.pone.0038136

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Peer-reviewed

Research Article

Tumor Necrosis Factor α Inhibits Expression of the Iron Regulating Hormone Hepcidin in Murine Models of Innate Colitis

Nanda Kumar N. Shanmugam,

Affiliation Mucosal Immunology Laboratory, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Shiri Ellenbogen,

Affiliation Mucosal Immunology Laboratory, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Estela Trebicka,

Affiliation Mucosal Immunology Laboratory, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Lijian Wang,

Affiliation Mucosal Immunology Laboratory, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Subhankar Mukhopadhyay,

Affiliations Developmental Immunology Laboratory, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
⨯
Adam Lacy-Hulbert,

Affiliations Developmental Immunology Laboratory, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Carey Ann Gallini,

Affiliation Departments of Immunology and Infectious Diseases and Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America
⨯
Wendy S. Garrett,

Affiliations Harvard Medical School, Boston, Massachusetts, United States of America, Departments of Immunology and Infectious Diseases and Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America, Dana-Farber Cancer Institute, Harvard School of Public Health, Boston, Massachusetts, United States of America
⨯
Bobby J. Cherayil

* E-mail: cherayil@helix.mgh.harvard.edu

Affiliations Mucosal Immunology Laboratory, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
⨯

Tumor Necrosis Factor α Inhibits Expression of the Iron Regulating Hormone Hepcidin in Murine Models of Innate Colitis

Nanda Kumar N. Shanmugam,
Shiri Ellenbogen,
Estela Trebicka,
Lijian Wang,
Subhankar Mukhopadhyay,
Adam Lacy-Hulbert,
Carey Ann Gallini,
Wendy S. Garrett,
Bobby J. Cherayil

Published: May 31, 2012
https://doi.org/10.1371/journal.pone.0038136

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