Inhibition of Intestinal Bile Acid Transporter Slc10a2 Improves Triglyceride Metabolism and Normalizes Elevated Plasma Glucose Levels in Mice

Thomas Lundåsen; Eva-Marie Andersson; Michael Snaith; Helena Lindmark; Johanna Lundberg; Ann-Margret Östlund-Lindqvist; Bo Angelin; Mats Rudling

doi:10.1371/journal.pone.0037787

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Peer-reviewed

Research Article

Inhibition of Intestinal Bile Acid Transporter Slc10a2 Improves Triglyceride Metabolism and Normalizes Elevated Plasma Glucose Levels in Mice

Thomas Lundåsen ,

Contributed equally to this work with: Thomas Lundåsen, Eva-Marie Andersson

Current address: Department of Molecular Therapeutics, Scripps Research Institute, Florida Campus, Jupiter, Florida, United States of America

Affiliation Karolinska Institute, Department of Endocrinology, Metabolism and Diabetes, Department of Medicine, and Molecular Nutrition Unit, Center for Biosciences, NOVUM, Karolinska University Hospital Huddinge, Stockholm, Sweden
⨯
Eva-Marie Andersson ,

Contributed equally to this work with: Thomas Lundåsen, Eva-Marie Andersson

Affiliation Bioscience, AstraZeneca R&D, Mölndal, Sweden
⨯
Michael Snaith,

Current address: MedImmune Ltd., Cambridge, United Kingdom

Affiliation Transgenics and Comparative Genomics, at AstraZeneca R&D, Mölndal, Sweden
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Helena Lindmark,

Affiliations Bioscience, AstraZeneca R&D, Mölndal, Sweden, Lead Generation, AstraZeneca R&D, Mölndal, Sweden
⨯
Johanna Lundberg,

Affiliation Karolinska Institute, Department of Endocrinology, Metabolism and Diabetes, Department of Medicine, and Molecular Nutrition Unit, Center for Biosciences, NOVUM, Karolinska University Hospital Huddinge, Stockholm, Sweden
⨯
Ann-Margret Östlund-Lindqvist,

Affiliation Bioscience, AstraZeneca R&D, Mölndal, Sweden
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Bo Angelin,

Affiliation Karolinska Institute, Department of Endocrinology, Metabolism and Diabetes, Department of Medicine, and Molecular Nutrition Unit, Center for Biosciences, NOVUM, Karolinska University Hospital Huddinge, Stockholm, Sweden
⨯
Mats Rudling

* E-mail: mats.rudling@ki.se

Affiliation Karolinska Institute, Department of Endocrinology, Metabolism and Diabetes, Department of Medicine, and Molecular Nutrition Unit, Center for Biosciences, NOVUM, Karolinska University Hospital Huddinge, Stockholm, Sweden
⨯

Inhibition of Intestinal Bile Acid Transporter Slc10a2 Improves Triglyceride Metabolism and Normalizes Elevated Plasma Glucose Levels in Mice

Thomas Lundåsen,
Eva-Marie Andersson,
Michael Snaith,
Helena Lindmark,
Johanna Lundberg,
Ann-Margret Östlund-Lindqvist,
Bo Angelin,
Mats Rudling

Published: May 25, 2012
https://doi.org/10.1371/journal.pone.0037787

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