Transient B Cell Depletion or Improved Transgene Expression by Codon Optimization Promote Tolerance to Factor VIII in Gene Therapy

• Brandon K. Sack,

  Affiliation Division of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida, Gainesville, Florida, United States of America

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• Sherin Merchant,

  Affiliation Division of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida, Gainesville, Florida, United States of America

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• David M. Markusic,

  Affiliation Division of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida, Gainesville, Florida, United States of America

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• Amit C. Nathwani,

  Affiliation Department of Haematology, UCL Cancer Institute, London, United Kingdom

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• Andrew M. Davidoff,

  Affiliation Department of Surgery, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

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• Barry J. Byrne,

  Affiliations Division of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida, Gainesville, Florida, United States of America, Powell Gene Therapy Center, University of Florida, Gainesville, Florida, United States of America

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• Roland W. Herzog

  * E-mail: rherzog@ufl.edu

  Affiliations Division of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida, Gainesville, Florida, United States of America, Powell Gene Therapy Center, University of Florida, Gainesville, Florida, United States of America

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