Crosstalk between Mitochondrial and Sarcoplasmic Reticulum Ca2+ Cycling Modulates Cardiac Pacemaker Cell Automaticity

Open Access

Peer-reviewed

Research Article

Crosstalk between Mitochondrial and Sarcoplasmic Reticulum Ca²⁺ Cycling Modulates Cardiac Pacemaker Cell Automaticity

Yael Yaniv,

Affiliation Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
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Harold A. Spurgeon,

Affiliation Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
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Alexey E. Lyashkov,

Affiliation Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
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Dongmei Yang,

Affiliation Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
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Bruce D. Ziman,

Affiliation Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
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Victor A. Maltsev,

Affiliation Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
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Edward G. Lakatta

* E-mail: LakattaE@mail.nih.gov

Affiliation Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
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Mitochondria
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Caffeine
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Simulation and modeling
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Cellular crosstalk
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Mitochondrial membrane
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Phosphorylation
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Intracellular membranes
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Action potentials
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