Sarcopenia Predicts Early Dose-Limiting Toxicities and Pharmacokinetics of Sorafenib in Patients with Hepatocellular Carcinoma

• Olivier Mir ,

  * E-mail: olivier.mir@cch.aphp.fr

  Affiliations Centre for Research on Angiogenesis Inhibitors (CERIA), Department of Medical Oncology, Cochin Teaching Hospital, AP-HP, Université Paris Descartes, Sorbonne Paris Cité, Paris, France, Department of Clinical Pharmacology, Cochin Teaching Hospital, AP-HP, Université Paris Descartes, Sorbonne Paris Cité, Paris, France

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• Romain Coriat,

  Affiliations Centre for Research on Angiogenesis Inhibitors (CERIA), Department of Medical Oncology, Cochin Teaching Hospital, AP-HP, Université Paris Descartes, Sorbonne Paris Cité, Paris, France, Department of Gastro-Enterology, Cochin Teaching Hospital, AP-HP, Université Paris Descartes, Sorbonne Paris Cité, Paris, France

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• Benoit Blanchet,

  Affiliations Centre for Research on Angiogenesis Inhibitors (CERIA), Department of Medical Oncology, Cochin Teaching Hospital, AP-HP, Université Paris Descartes, Sorbonne Paris Cité, Paris, France, Laboratory of Pharmacology and Toxicology, Cochin Teaching Hospital, AP-HP, Université Paris Descartes, Sorbonne Paris Cité, Paris, France

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• Jean-Philippe Durand,

  Affiliation Centre for Research on Angiogenesis Inhibitors (CERIA), Department of Medical Oncology, Cochin Teaching Hospital, AP-HP, Université Paris Descartes, Sorbonne Paris Cité, Paris, France

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• Pascaline Boudou-Rouquette,

  Affiliation Centre for Research on Angiogenesis Inhibitors (CERIA), Department of Medical Oncology, Cochin Teaching Hospital, AP-HP, Université Paris Descartes, Sorbonne Paris Cité, Paris, France

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• Judith Michels,

  Affiliation Centre for Research on Angiogenesis Inhibitors (CERIA), Department of Medical Oncology, Cochin Teaching Hospital, AP-HP, Université Paris Descartes, Sorbonne Paris Cité, Paris, France

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• Stanislas Ropert,

  Affiliation Centre for Research on Angiogenesis Inhibitors (CERIA), Department of Medical Oncology, Cochin Teaching Hospital, AP-HP, Université Paris Descartes, Sorbonne Paris Cité, Paris, France

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• Michel Vidal,

  Affiliation Laboratory of Pharmacology and Toxicology, Cochin Teaching Hospital, AP-HP, Université Paris Descartes, Sorbonne Paris Cité, Paris, France

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• Stanislas Pol,

  Affiliation Department of Hepatology and INSERM U1016, Cochin Teaching Hospital, AP-HP, Université Paris Descartes, Sorbonne Paris Cité, Paris, France

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• Stanislas Chaussade,

  Affiliation Department of Gastro-Enterology, Cochin Teaching Hospital, AP-HP, Université Paris Descartes, Sorbonne Paris Cité, Paris, France

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• François Goldwasser

  Affiliation Centre for Research on Angiogenesis Inhibitors (CERIA), Department of Medical Oncology, Cochin Teaching Hospital, AP-HP, Université Paris Descartes, Sorbonne Paris Cité, Paris, France

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