Activation of BKCa Channels in Zoledronic Acid-Induced Apoptosis of MDA-MB-231 Breast Cancer Cells

Yu-Guang Ma; Wen-Chao Liu; Shuo Dong; Cheng Du; Xiao-Jun Wang; Jin-Sheng Li; Xiao-Ping Xie; Li Wu; Da-Chang Ma; Zhi-Bin Yu; Man-Jiang Xie

doi:10.1371/journal.pone.0037451

Loading metrics

Open Access

Peer-reviewed

Research Article

Activation of BK_Ca Channels in Zoledronic Acid-Induced Apoptosis of MDA-MB-231 Breast Cancer Cells

Yu-Guang Ma ,

Contributed equally to this work with: Yu-Guang Ma, Wen-Chao Liu

Affiliations Department of Clinical Oncology, Xijing Hospital, Fourth Military Medical University, Xi'an, China, Department of Breast Disease, First Hospital of Lanzhou University, Lanzhou, China
⨯
Wen-Chao Liu ,

Contributed equally to this work with: Yu-Guang Ma, Wen-Chao Liu

* E-mail: liuch@fmmu.edu.cn (WCL); manjiangxie@hotmail.com (MJX)

Affiliation Department of Clinical Oncology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
⨯
Shuo Dong,

Affiliation Department of Medicine, Baylor College of Medicine, Houston, United States of America
⨯
Cheng Du,

Affiliation Department of Clinical Oncology, Xijing Hospital, Fourth Military Medical University, Xi'an, China
⨯
Xiao-Jun Wang,

Affiliation Key Laboratory of Aerospace Medicine, Department of Aerospace Physiology, Fourth Military Medical University, Ministry of China, Xi'an, China
⨯
Jin-Sheng Li,

Affiliation Key Laboratory of Aerospace Medicine, Department of Aerospace Physiology, Fourth Military Medical University, Ministry of China, Xi'an, China
⨯
Xiao-Ping Xie,

Affiliation Key Laboratory of Aerospace Medicine, Department of Aerospace Physiology, Fourth Military Medical University, Ministry of China, Xi'an, China
⨯
Li Wu,

Affiliation Department of Breast Disease, First Hospital of Lanzhou University, Lanzhou, China
⨯
Da-Chang Ma,

Affiliation Department of Breast Disease, First Hospital of Lanzhou University, Lanzhou, China
⨯
Zhi-Bin Yu,

Affiliation Key Laboratory of Aerospace Medicine, Department of Aerospace Physiology, Fourth Military Medical University, Ministry of China, Xi'an, China
⨯
Man-Jiang Xie

* E-mail: liuch@fmmu.edu.cn (WCL); manjiangxie@hotmail.com (MJX)

Affiliation Key Laboratory of Aerospace Medicine, Department of Aerospace Physiology, Fourth Military Medical University, Ministry of China, Xi'an, China
⨯

Activation of BK_Ca Channels in Zoledronic Acid-Induced Apoptosis of MDA-MB-231 Breast Cancer Cells

Yu-Guang Ma,
Wen-Chao Liu,
Shuo Dong,
Cheng Du,
Xiao-Jun Wang,
Jin-Sheng Li,
Xiao-Ping Xie,
Li Wu,
Da-Chang Ma,
Zhi-Bin Yu

Published: May 24, 2012
https://doi.org/10.1371/journal.pone.0037451

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
Breast cancer
Is the Subject Area "Breast cancer" applicable to this article?

Thanks for your feedback.
Cancer treatment
Is the Subject Area "Cancer treatment" applicable to this article?

Thanks for your feedback.
Membrane potential
Is the Subject Area "Membrane potential" applicable to this article?

Thanks for your feedback.
Depolarization
Is the Subject Area "Depolarization" applicable to this article?

Thanks for your feedback.
Cloning
Is the Subject Area "Cloning" applicable to this article?

Thanks for your feedback.
Mitochondria
Is the Subject Area "Mitochondria" applicable to this article?

Thanks for your feedback.
Mitochondrial membrane
Is the Subject Area "Mitochondrial membrane" applicable to this article?

Thanks for your feedback.