Evolutionary Constraint Helps Unmask a Splicing Regulatory Region in BRCA1 Exon 11

Open Access

Peer-reviewed

Research Article

Michela Raponi ,

Contributed equally to this work with: Michela Raponi, Andrew G. L. Douglas

Affiliation Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
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Andrew G. L. Douglas ,

Contributed equally to this work with: Michela Raponi, Andrew G. L. Douglas

Affiliations Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom, Wessex Clinical Genetics Service, Southampton University Hospitals NHS Trust, Southampton, United Kingdom
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Claudia Tammaro,

Affiliation Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
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David I. Wilson,

Affiliation Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
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Diana Baralle

* E-mail: D.Baralle@soton.ac.uk

Affiliations Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom, Wessex Clinical Genetics Service, Southampton University Hospitals NHS Trust, Southampton, United Kingdom
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Genetic causes of cancer
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Nucleotides
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Breast cancer
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Alternative splicing
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Transfection
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Introns
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Substitution mutation
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Polymerase chain reaction
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