Induction of Cellular Senescence by Doxorubicin Is Associated with Upregulated miR-375 and Induction of Autophagy in K562 Cells

Ming-Yu Yang; Pai-Mei Lin; Yi-Chang Liu; Hui-Hua Hsiao; Wen-Chi Yang; Jui-Feng Hsu; Cheng-Ming Hsu; Sheng-Fung Lin

doi:10.1371/journal.pone.0037205

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Open Access

Peer-reviewed

Research Article

Induction of Cellular Senescence by Doxorubicin Is Associated with Upregulated miR-375 and Induction of Autophagy in K562 Cells

Ming-Yu Yang ,

* E-mail: yangmy@mail.cgu.edu.tw (MYY); shlin@cc.kmu.edu.tw (SFL)

Affiliations Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan, Division of Hematology-Oncology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
⨯
Pai-Mei Lin,

Affiliation Department of Nursing, I-Shou University, Kaohsiung, Taiwan
⨯
Yi-Chang Liu,

Affiliations Division of Hematology-Oncology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, Faculty of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
⨯
Hui-Hua Hsiao,

Affiliations Division of Hematology-Oncology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, Faculty of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
⨯
Wen-Chi Yang,

Affiliation Division of Hematology-Oncology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
⨯
Jui-Feng Hsu,

Affiliation Division of Hematology-Oncology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
⨯
Cheng-Ming Hsu,

Affiliation Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
⨯
Sheng-Fung Lin

* E-mail: yangmy@mail.cgu.edu.tw (MYY); shlin@cc.kmu.edu.tw (SFL)

Affiliations Division of Hematology-Oncology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, Faculty of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
⨯

Induction of Cellular Senescence by Doxorubicin Is Associated with Upregulated miR-375 and Induction of Autophagy in K562 Cells

Ming-Yu Yang,
Pai-Mei Lin,
Yi-Chang Liu,
Hui-Hua Hsiao,
Wen-Chi Yang,
Jui-Feng Hsu,
Cheng-Ming Hsu,
Sheng-Fung Lin

Published: May 11, 2012
https://doi.org/10.1371/journal.pone.0037205

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MicroRNAs
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Gene expression
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Senescence
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Autophagic cell death
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