A Novel Chromone Derivative with Anti-Inflammatory Property via Inhibition of ROS-Dependent Activation of TRAF6-ASK1-p38 Pathway

Hailiang Liu; Rui Xu; Lili Feng; Wenjie Guo; Ning Cao; Cheng Qian; Peng Teng; Lu Wang; Xuefeng Wu; Yang Sun; Jianxin Li; Yan Shen; Qiang Xu

doi:10.1371/journal.pone.0037168

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Open Access

Peer-reviewed

Research Article

A Novel Chromone Derivative with Anti-Inflammatory Property via Inhibition of ROS-Dependent Activation of TRAF6-ASK1-p38 Pathway

Hailiang Liu,

Affiliation State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
⨯
Rui Xu,

Affiliation State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
⨯
Lili Feng,

Affiliation State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
⨯
Wenjie Guo,

Affiliation State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
⨯
Ning Cao,

Affiliation State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
⨯
Cheng Qian,

Affiliation State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
⨯
Peng Teng,

Affiliation State Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China
⨯
Lu Wang,

Affiliation State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
⨯
Xuefeng Wu,

Affiliation State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
⨯
Yang Sun,

Affiliation State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
⨯
Jianxin Li,

Affiliation State Key Lab of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China
⨯
Yan Shen ,

* E-mail: molpharm@163.com (QX); shenyan@nju.edu.cn (YS)

Affiliation State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
⨯
Qiang Xu

* E-mail: molpharm@163.com (QX); shenyan@nju.edu.cn (YS)

Affiliation State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China
⨯

A Novel Chromone Derivative with Anti-Inflammatory Property via Inhibition of ROS-Dependent Activation of TRAF6-ASK1-p38 Pathway

Hailiang Liu,
Rui Xu,
Lili Feng,
Wenjie Guo,
Ning Cao,
Cheng Qian,
Peng Teng,
Lu Wang,
Xuefeng Wu,
Yang Sun

Published: June 15, 2012
https://doi.org/10.1371/journal.pone.0037168

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