Phosphorylation of Nicastrin by SGK1 Leads to Its Degradation through Lysosomal and Proteasomal Pathways

Jung-Soon Mo; Ji-Hye Yoon; Ji-Ae Hong; Mi-Yeon Kim; Eun-Jung Ann; Ji-Seon Ahn; Su-Man Kim; Hyeong-Jin Baek; Florian Lang; Eui-Ju Choi; Hee-Sae Park

doi:10.1371/journal.pone.0037111

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Open Access

Peer-reviewed

Research Article

Phosphorylation of Nicastrin by SGK1 Leads to Its Degradation through Lysosomal and Proteasomal Pathways

Jung-Soon Mo ,

Contributed equally to this work with: Jung-Soon Mo, Ji-Hye Yoon, Ji-Ae Hong

Affiliation School of Biological Sciences and Technology, Hormone Research Center, Chonnam National University, Gwangju, Republic of Korea
⨯
Ji-Hye Yoon ,

Contributed equally to this work with: Jung-Soon Mo, Ji-Hye Yoon, Ji-Ae Hong

Affiliation School of Biological Sciences and Technology, Hormone Research Center, Chonnam National University, Gwangju, Republic of Korea
⨯
Ji-Ae Hong ,

Contributed equally to this work with: Jung-Soon Mo, Ji-Hye Yoon, Ji-Ae Hong

Affiliation School of Biological Sciences and Technology, Hormone Research Center, Chonnam National University, Gwangju, Republic of Korea
⨯
Mi-Yeon Kim,

Affiliation School of Biological Sciences and Technology, Hormone Research Center, Chonnam National University, Gwangju, Republic of Korea
⨯
Eun-Jung Ann,

Affiliation School of Biological Sciences and Technology, Hormone Research Center, Chonnam National University, Gwangju, Republic of Korea
⨯
Ji-Seon Ahn,

Affiliation School of Biological Sciences and Technology, Hormone Research Center, Chonnam National University, Gwangju, Republic of Korea
⨯
Su-Man Kim,

Affiliation School of Biological Sciences and Technology, Hormone Research Center, Chonnam National University, Gwangju, Republic of Korea
⨯
Hyeong-Jin Baek,

Affiliation School of Biological Sciences and Technology, Hormone Research Center, Chonnam National University, Gwangju, Republic of Korea
⨯
Florian Lang,

Affiliation Department of Physiology, University of Tübingen, Tübingen, Germany
⨯
Eui-Ju Choi,

Affiliation School of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea
⨯
Hee-Sae Park

* E-mail: proteome@jnu.ac.kr

Affiliation School of Biological Sciences and Technology, Hormone Research Center, Chonnam National University, Gwangju, Republic of Korea
⨯

Phosphorylation of Nicastrin by SGK1 Leads to Its Degradation through Lysosomal and Proteasomal Pathways

Jung-Soon Mo,
Ji-Hye Yoon,
Ji-Ae Hong,
Mi-Yeon Kim,
Eun-Jung Ann,
Ji-Seon Ahn,
Su-Man Kim,
Hyeong-Jin Baek,
Florian Lang,
Eui-Ju Choi

Published: May 10, 2012
https://doi.org/10.1371/journal.pone.0037111

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Immunoprecipitation
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Transfection
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Phosphorylation
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