Direct and Allosteric Inhibition of the FGF2/HSPGs/FGFR1 Ternary Complex Formation by an Antiangiogenic, Thrombospondin-1-Mimic Small Molecule

Katiuscia Pagano; Rubben Torella; Chiara Foglieni; Antonella Bugatti; Simona Tomaselli; Lucia Zetta; Marco Presta; Marco Rusnati; Giulia Taraboletti; Giorgio Colombo; Laura Ragona

doi:10.1371/journal.pone.0036990

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Peer-reviewed

Research Article

Direct and Allosteric Inhibition of the FGF2/HSPGs/FGFR1 Ternary Complex Formation by an Antiangiogenic, Thrombospondin-1-Mimic Small Molecule

Katiuscia Pagano,

Affiliation Laboratorio NMR, Istituto per lo Studio delle Macromolecole, Consiglio Nazionale delle Ricerche, Milano, Italy
⨯
Rubben Torella,

Affiliation Istituto di Chimica del Riconoscimento Molecolare, Consiglio Nazionale delle Ricerche, Milano, Italy
⨯
Chiara Foglieni,

Affiliation Department of Oncology, Mario Negri Institute for Pharmacological Research, Bergamo, Italy
⨯
Antonella Bugatti,

Affiliation Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, Brescia, Italy
⨯
Simona Tomaselli,

Affiliation Laboratorio NMR, Istituto per lo Studio delle Macromolecole, Consiglio Nazionale delle Ricerche, Milano, Italy
⨯
Lucia Zetta,

Affiliation Laboratorio NMR, Istituto per lo Studio delle Macromolecole, Consiglio Nazionale delle Ricerche, Milano, Italy
⨯
Marco Presta,

Affiliation Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, Brescia, Italy
⨯
Marco Rusnati,

Affiliation Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, Brescia, Italy
⨯
Giulia Taraboletti,

Affiliation Department of Oncology, Mario Negri Institute for Pharmacological Research, Bergamo, Italy
⨯
Giorgio Colombo ,

* E-mail: laura.ragona@ismac.cnr.it (LR); g.colombo@icrm.cnr.it (GC)

Affiliation Istituto di Chimica del Riconoscimento Molecolare, Consiglio Nazionale delle Ricerche, Milano, Italy
⨯
Laura Ragona

* E-mail: laura.ragona@ismac.cnr.it (LR); g.colombo@icrm.cnr.it (GC)

Affiliation Laboratorio NMR, Istituto per lo Studio delle Macromolecole, Consiglio Nazionale delle Ricerche, Milano, Italy
⨯

Direct and Allosteric Inhibition of the FGF2/HSPGs/FGFR1 Ternary Complex Formation by an Antiangiogenic, Thrombospondin-1-Mimic Small Molecule

Katiuscia Pagano,
Rubben Torella,
Chiara Foglieni,
Antonella Bugatti,
Simona Tomaselli,
Lucia Zetta,
Marco Presta,
Marco Rusnati,
Giulia Taraboletti,
Giorgio Colombo

Published: May 14, 2012
https://doi.org/10.1371/journal.pone.0036990

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