Epigenetic Repression of RARRES1 Is Mediated by Methylation of a Proximal Promoter and a Loss of CTCF Binding

Zhengang Peng; Rulong Shen; Ying-Wei Li; Kun-Yu Teng; Charles L. Shapiro; Huey-Jen L. Lin

doi:10.1371/journal.pone.0036891

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Research Article

Epigenetic Repression of RARRES1 Is Mediated by Methylation of a Proximal Promoter and a Loss of CTCF Binding

Zhengang Peng,

Affiliations Division of Medical Technology, School of Allied Medical Professions, the Ohio State University Medical Center, Columbus, Ohio, United States of America, Molecular Biology and Cancer Genetics Program, Comprehensive Cancer Center, the Ohio State University Medical Center, Columbus, Ohio, United States of America
⨯
Rulong Shen,

Affiliation Department of Pathology, the Ohio State University Medical Center, Columbus, Ohio, United States of America
⨯
Ying-Wei Li,

Affiliations Division of Medical Technology, School of Allied Medical Professions, the Ohio State University Medical Center, Columbus, Ohio, United States of America, Molecular Biology and Cancer Genetics Program, Comprehensive Cancer Center, the Ohio State University Medical Center, Columbus, Ohio, United States of America
⨯
Kun-Yu Teng,

Affiliations Division of Medical Technology, School of Allied Medical Professions, the Ohio State University Medical Center, Columbus, Ohio, United States of America, Molecular Biology and Cancer Genetics Program, Comprehensive Cancer Center, the Ohio State University Medical Center, Columbus, Ohio, United States of America
⨯
Charles L. Shapiro,

Affiliation Department of Medical Oncology, the Ohio State University Medical Center, Columbus, Ohio, United States of America
⨯
Huey-Jen L. Lin

* E-mail: hueyjenlin@gmail.com

Affiliations Division of Medical Technology, School of Allied Medical Professions, the Ohio State University Medical Center, Columbus, Ohio, United States of America, Molecular Biology and Cancer Genetics Program, Comprehensive Cancer Center, the Ohio State University Medical Center, Columbus, Ohio, United States of America, Department of Medical Technology, University of Delaware, Newark, Delaware, United States of America
⨯

Epigenetic Repression of RARRES1 Is Mediated by Methylation of a Proximal Promoter and a Loss of CTCF Binding

Zhengang Peng,
Rulong Shen,
Ying-Wei Li,
Kun-Yu Teng,
Charles L. Shapiro,
Huey-Jen L. Lin

Published: May 17, 2012
https://doi.org/10.1371/journal.pone.0036891

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DNA methylation
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