Estrogen Modulates NFκB Signaling by Enhancing IκBα Levels and Blocking p65 Binding at the Promoters of Inflammatory Genes via Estrogen Receptor-β

Dongqi Xing; Suzanne Oparil; Hao Yu; Kaizheng Gong; Wenguang Feng; Jonathan Black; Yiu-Fai Chen; Susan Nozell

doi:10.1371/journal.pone.0036890

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Open Access

Peer-reviewed

Research Article

Estrogen Modulates NFκB Signaling by Enhancing IκBα Levels and Blocking p65 Binding at the Promoters of Inflammatory Genes via Estrogen Receptor-β

Dongqi Xing ,

* E-mail: dqxing@uab.edu

Affiliation Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Suzanne Oparil,

Affiliation Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Hao Yu,

Affiliation Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Kaizheng Gong,

Affiliations Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Department of Cardiology, The Second Clinical Medical School, Yangzhou University, Yangzhou, China
⨯
Wenguang Feng,

Affiliation Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Jonathan Black,

Affiliation Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Yiu-Fai Chen,

Affiliation Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Susan Nozell

Affiliation Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯

Estrogen Modulates NFκB Signaling by Enhancing IκBα Levels and Blocking p65 Binding at the Promoters of Inflammatory Genes via Estrogen Receptor-β

Dongqi Xing,
Suzanne Oparil,
Hao Yu,
Kaizheng Gong,
Wenguang Feng,
Jonathan Black,
Yiu-Fai Chen,
Susan Nozell

Published: June 19, 2012
https://doi.org/10.1371/journal.pone.0036890

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Inflammation
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Chromatin immunoprecipitation
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DNA transcription
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Gene expression
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Signal inhibition
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Reverse transcriptase-polymerase chain reaction
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Immunoprecipitation
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Messenger RNA
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