A General Strategy to Endow Natural Fusion-protein-Derived Peptides with Potent Antiviral Activity

Antonello Pessi; Annunziata Langella; Elena Capitò; Silvia Ghezzi; Elisa Vicenzi; Guido Poli; Thomas Ketas; Cyrille Mathieu; Riccardo Cortese; Branka Horvat; Anne Moscona; Matteo Porotto

doi:10.1371/journal.pone.0036833

Loading metrics

Open Access

Peer-reviewed

Research Article

A General Strategy to Endow Natural Fusion-protein-Derived Peptides with Potent Antiviral Activity

Antonello Pessi ,

* E-mail: a.pessi@peptipharma.it (AP); map2028@med.cornell.edu (MP)

Affiliation PeptiPharma, Pomezia, Rome, Italy
⨯
Annunziata Langella,

Affiliation Merck Serono, Guidonia Montecelio, Rome, Italy
⨯
Elena Capitò,

Affiliation BASF Italia, Pontecchio Marconi, Bologna, Italy
⨯
Silvia Ghezzi,

Affiliation Viral Pathogens and Biosafety, Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
⨯
Elisa Vicenzi,

Affiliation Viral Pathogens and Biosafety, Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
⨯
Guido Poli,

Affiliations AIDS Immunopathogenesis Units, Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy, Vita-Salute San Raffaele University, School of Medicine, Milan, Italy
⨯
Thomas Ketas,

Affiliation Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, United States of America
⨯
Cyrille Mathieu,

Affiliations INSERM, Ecole Normale Supérieure de Lyon, Lyon, France, Pedriatics, Weill Medical College of Cornell University, New York, New York, United States of America
⨯
Riccardo Cortese,

Affiliation CEINGE, Naples, Italy
⨯
Branka Horvat,

Affiliations INSERM, Ecole Normale Supérieure de Lyon, Lyon, France, IFR128 BioSciences Lyon-Gerland Lyon-Sud, University of Lyon, Lyon, France
⨯
Anne Moscona,

Affiliations Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, United States of America, Pedriatics, Weill Medical College of Cornell University, New York, New York, United States of America
⨯
Matteo Porotto

* E-mail: a.pessi@peptipharma.it (AP); map2028@med.cornell.edu (MP)

Affiliation Pedriatics, Weill Medical College of Cornell University, New York, New York, United States of America
⨯

A General Strategy to Endow Natural Fusion-protein-Derived Peptides with Potent Antiviral Activity

Antonello Pessi,
Annunziata Langella,
Elena Capitò,
Silvia Ghezzi,
Elisa Vicenzi,
Guido Poli,
Thomas Ketas,
Cyrille Mathieu,
Riccardo Cortese,
Branka Horvat

Published: May 16, 2012
https://doi.org/10.1371/journal.pone.0036833

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Cell fusion
Is the Subject Area "Cell fusion" applicable to this article?

Thanks for your feedback.
Cholesterol
Is the Subject Area "Cholesterol" applicable to this article?

Thanks for your feedback.
Dimers
Is the Subject Area "Dimers" applicable to this article?

Thanks for your feedback.
HIV-1
Is the Subject Area "HIV-1" applicable to this article?

Thanks for your feedback.
Monomers
Is the Subject Area "Monomers" applicable to this article?

Thanks for your feedback.
Respiratory infections
Is the Subject Area "Respiratory infections" applicable to this article?

Thanks for your feedback.
Dimerization
Is the Subject Area "Dimerization" applicable to this article?

Thanks for your feedback.
Viral entry
Is the Subject Area "Viral entry" applicable to this article?

Thanks for your feedback.