MEK1 Inhibits Cardiac PPARα Activity by Direct Interaction and Prevents Its Nuclear Localization

Open Access

Peer-reviewed

Research Article

Hamid el Azzouzi,

Affiliations Interuniversity Cardiology Institute Netherlands, Royal Netherlands Academy of Sciences, Utrecht, The Netherlands, Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
⨯
Stefanos Leptidis,

Affiliations Interuniversity Cardiology Institute Netherlands, Royal Netherlands Academy of Sciences, Utrecht, The Netherlands, Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
⨯
Meriem Bourajjaj,

Affiliation Interuniversity Cardiology Institute Netherlands, Royal Netherlands Academy of Sciences, Utrecht, The Netherlands
⨯
Marc van Bilsen,

Affiliation Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
⨯
Paula A. da Costa Martins,

Affiliations Interuniversity Cardiology Institute Netherlands, Royal Netherlands Academy of Sciences, Utrecht, The Netherlands, Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
⨯
Leon J. De Windt

* E-mail: l.dewindt@maastrichtuniversity.nl

Affiliation Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
⨯

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Co-immunoprecipitation
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Heart
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MAPK signaling cascades
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Phosphorylation
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Protein kinase signaling cascade
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Exercise
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PPAR signaling
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Transfection
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