Ordered Self-Assembly Mechanism of a Spherical Oncoprotein Oligomer Triggered by Zinc Removal and Stabilized by an Intrinsically Disordered Domain

Open Access

Peer-reviewed

Research Article

Clara Smal,

Affiliation Fundación Instituto Leloir and Instituto de Investigaciones Bioquímicas-Conicet, Buenos Aires, Argentina
⨯
Leonardo G. Alonso,

Affiliation XBio Inc., Buenos Aires, Argentina
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Diana E. Wetzler,

Affiliation Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires, Argentina
⨯
Angeles Heer,

Affiliation Fundación Instituto Leloir and Instituto de Investigaciones Bioquímicas-Conicet, Buenos Aires, Argentina
⨯
Gonzalo de Prat Gay

* E-mail: gpg@leloir.org.ar

Affiliation Fundación Instituto Leloir and Instituto de Investigaciones Bioquímicas-Conicet, Buenos Aires, Argentina
⨯

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Zinc
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Amyloid proteins
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Oligomers
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Intrinsically disordered proteins
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Dimers
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Molecular self assembly
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Monomers
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Atomic force microscopy
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