A Novel Solid-Phase Site-Specific PEGylation Enhances the In Vitro and In Vivo Biostabilty of Recombinant Human Keratinocyte Growth Factor 1

Zhifeng Huang; Guanghui Zhu; Chuanchuan Sun; Jingui Zhang; Yi Zhang; Youting Zhang; Chaohui Ye; Xiaojie Wang; Dariush Ilghari; Xiaokun Li

doi:10.1371/journal.pone.0036423

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Open Access

Peer-reviewed

Research Article

A Novel Solid-Phase Site-Specific PEGylation Enhances the In Vitro and In Vivo Biostabilty of Recombinant Human Keratinocyte Growth Factor 1

Zhifeng Huang ,

Contributed equally to this work with: Zhifeng Huang, Guanghui Zhu, Chuanchuan Sun

Affiliation Key Laboratory of Biotechnology and Pharmaceutical Engineering of Zhejiang Province, Wenzhou Medical College, Wenzhou, China
⨯
Guanghui Zhu ,

Contributed equally to this work with: Zhifeng Huang, Guanghui Zhu, Chuanchuan Sun

Affiliation The 2nd Affiliated Hospital Medical Center, Wenzhou Medical College, Wenzhou, China
⨯
Chuanchuan Sun ,

Contributed equally to this work with: Zhifeng Huang, Guanghui Zhu, Chuanchuan Sun

Affiliation Key Laboratory of Biotechnology and Pharmaceutical Engineering of Zhejiang Province, Wenzhou Medical College, Wenzhou, China
⨯
Jingui Zhang,

Affiliation Key Laboratory of Biotechnology and Pharmaceutical Engineering of Zhejiang Province, Wenzhou Medical College, Wenzhou, China
⨯
Yi Zhang,

Affiliation Key Laboratory of Biotechnology and Pharmaceutical Engineering of Zhejiang Province, Wenzhou Medical College, Wenzhou, China
⨯
Youting Zhang,

Affiliation The 2nd Affiliated Hospital Medical Center, Wenzhou Medical College, Wenzhou, China
⨯
Chaohui Ye,

Affiliation Key Laboratory of Biotechnology and Pharmaceutical Engineering of Zhejiang Province, Wenzhou Medical College, Wenzhou, China
⨯
Xiaojie Wang,

Affiliation Key Laboratory of Biotechnology and Pharmaceutical Engineering of Zhejiang Province, Wenzhou Medical College, Wenzhou, China
⨯
Dariush Ilghari ,

* E-mail: Dariush.Ilghari@nyumc.org (DI); proflxk@163.com (XL)

Affiliation Department of Pharmacology, New York University School of Medicine, New York, New York, United States of America
⨯
Xiaokun Li

* E-mail: Dariush.Ilghari@nyumc.org (DI); proflxk@163.com (XL)

Affiliations Key Laboratory of Biotechnology and Pharmaceutical Engineering of Zhejiang Province, Wenzhou Medical College, Wenzhou, China, Normal Bethune Medical College, Jilin University, Changchun, China
⨯

A Novel Solid-Phase Site-Specific PEGylation Enhances the In Vitro and In Vivo Biostabilty of Recombinant Human Keratinocyte Growth Factor 1

Zhifeng Huang,
Guanghui Zhu,
Chuanchuan Sun,
Jingui Zhang,
Yi Zhang,
Youting Zhang,
Chaohui Ye,
Xiaojie Wang,
Dariush Ilghari,
Xiaokun Li

Published: May 4, 2012
https://doi.org/10.1371/journal.pone.0036423

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Elimination half-life calculation
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