Active PI3K Pathway Causes an Invasive Phenotype Which Can Be Reversed or Promoted by Blocking the Pathway at Divergent Nodes

Jeffrey J. Wallin; Jane Guan; Kyle A. Edgar; Wei Zhou; Ross Francis; Anthony C. Torres; Peter M. Haverty; Jeffrey Eastham-Anderson; Sabrina Arena; Alberto Bardelli; Sue Griffin; John E. Goodall; Kyla M. Grimshaw; Klaus P. Hoeflich; Christopher Torrance; Marcia Belvin; Lori S. Friedman

doi:10.1371/journal.pone.0036402

Loading metrics

Open Access

Peer-reviewed

Research Article

Active PI3K Pathway Causes an Invasive Phenotype Which Can Be Reversed or Promoted by Blocking the Pathway at Divergent Nodes

Jeffrey J. Wallin ,

* E-mail: jwallin@gene.com

Affiliation Departments of Cancer Signaling and Translational Oncology, Genentech, Inc., South San Francisco, California, United States of America
⨯
Jane Guan,

Affiliation Departments of Cancer Signaling and Translational Oncology, Genentech, Inc., South San Francisco, California, United States of America
⨯
Kyle A. Edgar,

Affiliation Departments of Cancer Signaling and Translational Oncology, Genentech, Inc., South San Francisco, California, United States of America
⨯
Wei Zhou,

Affiliation Departments of Cancer Signaling and Translational Oncology, Genentech, Inc., South San Francisco, California, United States of America
⨯
Ross Francis,

Affiliation Departments of Cancer Signaling and Translational Oncology, Genentech, Inc., South San Francisco, California, United States of America
⨯
Anthony C. Torres,

Affiliation Departments of Cancer Signaling and Translational Oncology, Genentech, Inc., South San Francisco, California, United States of America
⨯
Peter M. Haverty,

Affiliation Bioinformatics, Genentech, Inc., South San Francisco, California, United States of America
⨯
Jeffrey Eastham-Anderson,

Affiliation Pathology, Genentech, Inc., South San Francisco, California, United States of America
⨯
Sabrina Arena,

Affiliation Laboratory of Molecular Genetics, Institute for Cancer Research and Treatment, University of Torino Medical School, Candiolo, Italy
⨯
Alberto Bardelli,

Affiliations Laboratory of Molecular Genetics, Institute for Cancer Research and Treatment, University of Torino Medical School, Candiolo, Italy, FIRC Institute of Molecular Oncology, Milan, Italy
⨯
Sue Griffin,

Affiliation Horizon Discovery Ltd., Cambridge, United Kingdom
⨯
John E. Goodall,

Affiliation Horizon Discovery Ltd., Cambridge, United Kingdom
⨯
Kyla M. Grimshaw,

Affiliation Horizon Discovery Ltd., Cambridge, United Kingdom
⨯
Klaus P. Hoeflich,

Affiliation Departments of Cancer Signaling and Translational Oncology, Genentech, Inc., South San Francisco, California, United States of America
⨯
Christopher Torrance,

Affiliation Horizon Discovery Ltd., Cambridge, United Kingdom
⨯
Marcia Belvin,

Affiliation Departments of Cancer Signaling and Translational Oncology, Genentech, Inc., South San Francisco, California, United States of America
⨯
[ ... ],
Lori S. Friedman

Affiliation Departments of Cancer Signaling and Translational Oncology, Genentech, Inc., South San Francisco, California, United States of America
⨯
[ view all ]
[ view less ]

Active PI3K Pathway Causes an Invasive Phenotype Which Can Be Reversed or Promoted by Blocking the Pathway at Divergent Nodes

Jeffrey J. Wallin,
Jane Guan,
Kyle A. Edgar,
Wei Zhou,
Ross Francis,
Anthony C. Torres,
Peter M. Haverty,
Jeffrey Eastham-Anderson,
Sabrina Arena,
Alberto Bardelli

Published: May 3, 2012
https://doi.org/10.1371/journal.pone.0036402

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Cloning
Is the Subject Area "Cloning" applicable to this article?

Thanks for your feedback.
Small interfering RNA
Is the Subject Area "Small interfering RNA" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Signal inhibition
Is the Subject Area "Signal inhibition" applicable to this article?

Thanks for your feedback.
Phenotypes
Is the Subject Area "Phenotypes" applicable to this article?

Thanks for your feedback.
Breast cancer
Is the Subject Area "Breast cancer" applicable to this article?

Thanks for your feedback.
Invasive tumors
Is the Subject Area "Invasive tumors" applicable to this article?

Thanks for your feedback.
Mutation
Is the Subject Area "Mutation" applicable to this article?

Thanks for your feedback.