A Novel Inhibitor of Human La Protein with Anti-HBV Activity Discovered by Structure-Based Virtual Screening and In Vitro Evaluation

Open Access

Peer-reviewed

Research Article

Jing Tang,

Affiliation Department of Pharmacy, First People's Hospital Affiliated with Shanghai JiaoTong University, Shanghai, China
⨯
Zhi-Min Huang,

Affiliation Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis, Chinese Ministry of Education, Shanghai JiaoTong University School of Medicine, Shanghai, China
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Ying-Yi Chen,

Affiliation Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis, Chinese Ministry of Education, Shanghai JiaoTong University School of Medicine, Shanghai, China
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Zhao-Hui Zhang,

Affiliation Department of Urology, Ruijin Hospital Luwan Branch Affiliated with Shanghai JiaoTong University School of Medicine, Shanghai, China
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Gao-Lin Liu ,

* E-mail: gaolinliu2009@gmail.com (G-LL); jzhang.dr@gmail.com (JZ)

Affiliation Department of Pharmacy, First People's Hospital Affiliated with Shanghai JiaoTong University, Shanghai, China
⨯
Jian Zhang

* E-mail: gaolinliu2009@gmail.com (G-LL); jzhang.dr@gmail.com (JZ)

Affiliation Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis, Chinese Ministry of Education, Shanghai JiaoTong University School of Medicine, Shanghai, China
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Small interfering RNA
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Hepatitis B virus
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RNA structure
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RNA-binding proteins
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Crystal structure
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DNA-binding proteins
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Library screening
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Nitrogen
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