Association of the CpG Methylation Pattern of the Proximal Insulin Gene Promoter with Type 1 Diabetes

Delphine Fradin; Sophie Le Fur; Clémence Mille; Nadia Naoui; Chris Groves; Diana Zelenika; Mark I. McCarthy; Mark Lathrop; Pierre Bougnères

doi:10.1371/journal.pone.0036278

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Peer-reviewed

Research Article

Association of the CpG Methylation Pattern of the Proximal Insulin Gene Promoter with Type 1 Diabetes

Delphine Fradin,

Affiliation Institut National de la Santé et de la Recherche Médicale U986 and Department of Pediatric Endocrinology, Bicêtre Hospital, Paris Sud University, Paris, France
⨯
Sophie Le Fur,

Affiliations Institut National de la Santé et de la Recherche Médicale U986 and Department of Pediatric Endocrinology, Bicêtre Hospital, Paris Sud University, Paris, France, ISIS-DIAB Cohort, Bicêtre and Saint Vincent de Paul Hospital, Paris, France
⨯
Clémence Mille,

Affiliations Institut National de la Santé et de la Recherche Médicale U986 and Department of Pediatric Endocrinology, Bicêtre Hospital, Paris Sud University, Paris, France, ISIS-DIAB Cohort, Bicêtre and Saint Vincent de Paul Hospital, Paris, France
⨯
Nadia Naoui,

Affiliations Institut National de la Santé et de la Recherche Médicale U986 and Department of Pediatric Endocrinology, Bicêtre Hospital, Paris Sud University, Paris, France, ISIS-DIAB Cohort, Bicêtre and Saint Vincent de Paul Hospital, Paris, France
⨯
Chris Groves,

Affiliation Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Headington, Oxford, United Kingdom
⨯
Diana Zelenika,

Affiliation Centre National de Génotypage, Evry, France
⨯
Mark I. McCarthy,

Affiliation Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Headington, Oxford, United Kingdom
⨯
Mark Lathrop,

Affiliation Centre National de Génotypage, Evry, France
⨯
Pierre Bougnères

* E-mail: pierre.bougneres@inserm.fr

Affiliations Institut National de la Santé et de la Recherche Médicale U986 and Department of Pediatric Endocrinology, Bicêtre Hospital, Paris Sud University, Paris, France, ISIS-DIAB Cohort, Bicêtre and Saint Vincent de Paul Hospital, Paris, France
⨯

Association of the CpG Methylation Pattern of the Proximal Insulin Gene Promoter with Type 1 Diabetes

Delphine Fradin,
Sophie Le Fur,
Clémence Mille,
Nadia Naoui,
Chris Groves,
Diana Zelenika,
Mark I. McCarthy,
Mark Lathrop,
Pierre Bougnères

Published: May 2, 2012
https://doi.org/10.1371/journal.pone.0036278

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DNA methylation
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Genetic loci
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Treatment guidelines
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Epigenetics
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Diabetes mellitus
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Single nucleotide polymorphisms
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Insulin
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Genomics
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