Myocardial Structural Alteration and Systolic Dysfunction in Preclinical Hypertrophic Cardiomyopathy Mutation Carriers

Kai Hang Yiu; Douwe E. Atsma; Victoria Delgado; Arnold C. T. Ng; Tomasz G. Witkowski; See Hooi Ewe; Dominique Auger; Eduard R. Holman; Anneke M. van Mil; Martijn H. Breuning; Hung Fat Tse; Jeroen J. Bax; Martin J. Schalij; Nina Ajmone Marsan

doi:10.1371/journal.pone.0036115

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Open Access

Peer-reviewed

Research Article

Myocardial Structural Alteration and Systolic Dysfunction in Preclinical Hypertrophic Cardiomyopathy Mutation Carriers

Kai Hang Yiu,

Affiliations Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands, Cardiology Division, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, The Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands
⨯
Douwe E. Atsma,

Affiliation Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
⨯
Victoria Delgado,

Affiliation Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
⨯
Arnold C. T. Ng,

Affiliation Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
⨯
Tomasz G. Witkowski,

Affiliation Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
⨯
See Hooi Ewe,

Affiliation Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
⨯
Dominique Auger,

Affiliation Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
⨯
Eduard R. Holman,

Affiliation Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
⨯
Anneke M. van Mil,

Affiliation Department of Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
⨯
Martijn H. Breuning,

Affiliation Department of Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
⨯
Hung Fat Tse,

Affiliation Cardiology Division, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong
⨯
Jeroen J. Bax,

Affiliation Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
⨯
Martin J. Schalij,

Affiliation Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
⨯
Nina Ajmone Marsan

* E-mail: n.ajmone@lumc.nl

Affiliations Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands, The Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands
⨯

Myocardial Structural Alteration and Systolic Dysfunction in Preclinical Hypertrophic Cardiomyopathy Mutation Carriers

Kai Hang Yiu,
Douwe E. Atsma,
Victoria Delgado,
Arnold C. T. Ng,
Tomasz G. Witkowski,
See Hooi Ewe,
Dominique Auger,
Eduard R. Holman,
Anneke M. van Mil,
Martijn H. Breuning

Published: May 4, 2012
https://doi.org/10.1371/journal.pone.0036115

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