Tumour Cell Generation of Inducible Regulatory T-Cells in Multiple Myeloma Is Contact-Dependent and Antigen-Presenting Cell-Independent

Sylvia Feyler; Gina B. Scott; Christopher Parrish; Sarah Jarmin; Paul Evans; Mike Short; Katherine McKinley; Peter J. Selby; Gordon Cook

doi:10.1371/journal.pone.0035981

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Open Access

Peer-reviewed

Research Article

Tumour Cell Generation of Inducible Regulatory T-Cells in Multiple Myeloma Is Contact-Dependent and Antigen-Presenting Cell-Independent

Sylvia Feyler ,

Contributed equally to this work with: Sylvia Feyler, Gina B. Scott

Affiliations Transplant Immunology Group, Academic Department of Haematology and Oncology, University of Leeds, Leeds, United Kingdom, Department of Haematology, Calderdale and Huddersfield NHS Trust, Huddersfield, United Kingdom
⨯
Gina B. Scott ,

Contributed equally to this work with: Sylvia Feyler, Gina B. Scott

Affiliation Transplant Immunology Group, Academic Department of Haematology and Oncology, University of Leeds, Leeds, United Kingdom
⨯
Christopher Parrish,

Affiliation Transplant Immunology Group, Academic Department of Haematology and Oncology, University of Leeds, Leeds, United Kingdom
⨯
Sarah Jarmin,

Affiliation Transplant Immunology Group, Academic Department of Haematology and Oncology, University of Leeds, Leeds, United Kingdom
⨯
Paul Evans,

Affiliation Haematological Malignancy Diagnostic Service, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
⨯
Mike Short,

Affiliation Haematological Malignancy Diagnostic Service, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
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Katherine McKinley,

Affiliation Department of Clinical Immunology, Leeds Teaching Hospitals Trust, Leeds, United Kingdom
⨯
Peter J. Selby,

Affiliation Academic Department of Haematology and Oncology, University of Leeds, Leeds, United Kingdom
⨯
Gordon Cook

* E-mail: Gordon.Cook@leedsth.nhs.uk

Affiliations Transplant Immunology Group, Academic Department of Haematology and Oncology, University of Leeds, Leeds, United Kingdom, Department of Haematology, St James’s Institute of Oncology, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
⨯

Tumour Cell Generation of Inducible Regulatory T-Cells in Multiple Myeloma Is Contact-Dependent and Antigen-Presenting Cell-Independent

Sylvia Feyler,
Gina B. Scott,
Christopher Parrish,
Sarah Jarmin,
Paul Evans,
Mike Short,
Katherine McKinley,
Peter J. Selby,
Gordon Cook

Published: May 29, 2012
https://doi.org/10.1371/journal.pone.0035981

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T cells
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Regulatory T cells
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Multiple myeloma
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Antigen-presenting cells
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