Translation Levels Control Multi-Spanning Membrane Protein Expression

Hok Seon Kim; James A. Ernst; Cecilia Brown; Jenny Bostrom; Germaine Fuh; Chingwei V. Lee; Arthur Huang; Richard L. Vandlen; Daniel G. Yansura

doi:10.1371/journal.pone.0035844

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Open Access

Peer-reviewed

Research Article

Translation Levels Control Multi-Spanning Membrane Protein Expression

Hok Seon Kim ,

Contributed equally to this work with: Hok Seon Kim, James A. Ernst

Affiliation Department of Antibody Engineering, Genentech Inc., South San Francisco, California, United States of America
⨯
James A. Ernst ,

Contributed equally to this work with: Hok Seon Kim, James A. Ernst

* E-mail: ernst.james@gene.com (JAE); yansura.dan@gene.com (DGY)

Affiliations Department of Early Discovery Biochemistry, Genentech Inc., South San Francisco, California, United States of America, Department of Protein Chemistry, Genentech Inc., South San Francisco, California, United States of America
⨯
Cecilia Brown,

Affiliation Department of Antibody Engineering, Genentech Inc., South San Francisco, California, United States of America
⨯
Jenny Bostrom,

Affiliations Department of Antibody Engineering, Genentech Inc., South San Francisco, California, United States of America, Department of Early Discovery Biochemistry, Genentech Inc., South San Francisco, California, United States of America
⨯
Germaine Fuh,

Affiliations Department of Antibody Engineering, Genentech Inc., South San Francisco, California, United States of America, Department of Early Discovery Biochemistry, Genentech Inc., South San Francisco, California, United States of America
⨯
Chingwei V. Lee,

Affiliations Department of Antibody Engineering, Genentech Inc., South San Francisco, California, United States of America, Department of Early Discovery Biochemistry, Genentech Inc., South San Francisco, California, United States of America
⨯
Arthur Huang,

Affiliation Department of Antibody Engineering, Genentech Inc., South San Francisco, California, United States of America
⨯
Richard L. Vandlen,

Affiliation Department of Protein Chemistry, Genentech Inc., South San Francisco, California, United States of America
⨯
Daniel G. Yansura

* E-mail: ernst.james@gene.com (JAE); yansura.dan@gene.com (DGY)

Affiliations Department of Antibody Engineering, Genentech Inc., South San Francisco, California, United States of America, Department of Protein Chemistry, Genentech Inc., South San Francisco, California, United States of America
⨯

Translation Levels Control Multi-Spanning Membrane Protein Expression

Hok Seon Kim,
James A. Ernst,
Cecilia Brown,
Jenny Bostrom,
Germaine Fuh,
Chingwei V. Lee,
Arthur Huang,
Richard L. Vandlen,
Daniel G. Yansura

Published: April 26, 2012
https://doi.org/10.1371/journal.pone.0035844

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Membrane proteins
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Cell membranes
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Integral membrane proteins
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Protein expression
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Eukaryotic membrane proteins
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Translation initiation
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G protein coupled receptors
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