Polymorphisms in Toll-Like Receptors 2, 4, and 9 Are Highly Associated with Hearing Loss in Survivors of Bacterial Meningitis

Gijs Th J. van Well; Marieke S. Sanders; Sander Ouburg; A. Marceline van Furth; Servaas A. Morré

doi:10.1371/journal.pone.0035837

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Peer-reviewed

Research Article

Polymorphisms in Toll-Like Receptors 2, 4, and 9 Are Highly Associated with Hearing Loss in Survivors of Bacterial Meningitis

Gijs Th J. van Well ,

Contributed equally to this work with: Gijs Th J. van Well, Marieke S. Sanders

Affiliations Department of Pediatric Infectious Diseases, Immunology and Rheumatology, VU University Medical Center, Amsterdam, The Netherlands, Department of Pediatrics, Maastricht University Medical Center, Maastricht, The Netherlands
⨯
Marieke S. Sanders ,

Contributed equally to this work with: Gijs Th J. van Well, Marieke S. Sanders

Affiliations Department of Pediatric Infectious Diseases, Immunology and Rheumatology, VU University Medical Center, Amsterdam, The Netherlands, Laboratory of Immunogenetics, Department of Medical Microbiology, VU University Medical Center, Amsterdam, The Netherlands, Department of Surgery, Antonius Hospital, Nieuwegein, The Netherlands
⨯
Sander Ouburg,

Affiliation Laboratory of Immunogenetics, Department of Medical Microbiology, VU University Medical Center, Amsterdam, The Netherlands
⨯
A. Marceline van Furth,

Affiliation Department of Pediatric Infectious Diseases, Immunology and Rheumatology, VU University Medical Center, Amsterdam, The Netherlands
⨯
Servaas A. Morré

* E-mail: samorretravel@yahoo.co.uk

Affiliations Laboratory of Immunogenetics, Department of Medical Microbiology, VU University Medical Center, Amsterdam, The Netherlands, Institute of Public Health Genomics, Department of Genetics and Cell Biology, Research Institutes CAPHRI (School for Public Health and Primary Care) and GROW (School for Oncology & Developmental Biology), Faculty of Health, Medicine & Life Sciences, University of Maastricht, Maastricht, The Netherlands
⨯

Polymorphisms in Toll-Like Receptors 2, 4, and 9 Are Highly Associated with Hearing Loss in Survivors of Bacterial Meningitis

Gijs Th J. van Well,
Marieke S. Sanders,
Sander Ouburg,
A. Marceline van Furth,
Servaas A. Morré

Published: May 25, 2012
https://doi.org/10.1371/journal.pone.0035837

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Toll-like receptors
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Deafness
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Single nucleotide polymorphisms
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Meningitis
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Immune response
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Bacterial meningitis
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Variant genotypes
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Meningococcal disease
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