Genetic Background Analysis of Protein C Deficiency Demonstrates a Recurrent Mutation Associated with Venous Thrombosis in Chinese Population

Liang Tang; Tao Guo; Rui Yang; Heng Mei; Huafang Wang; Xuan Lu; Jianming Yu; Qingyun Wang; Yu Hu

doi:10.1371/journal.pone.0035773

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Peer-reviewed

Research Article

Genetic Background Analysis of Protein C Deficiency Demonstrates a Recurrent Mutation Associated with Venous Thrombosis in Chinese Population

Liang Tang,

Affiliations Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China, Hubei Clinical and Research Center of Thrombosis and Hemostasis, Wuhan, Hubei, People's Republic of China, Targeted Biotherapy Key Laboratory of Ministry of Education, Wuhan, Hubei, People's Republic of China
⨯
Tao Guo,

Affiliations Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China, Hubei Clinical and Research Center of Thrombosis and Hemostasis, Wuhan, Hubei, People's Republic of China, Targeted Biotherapy Key Laboratory of Ministry of Education, Wuhan, Hubei, People's Republic of China
⨯
Rui Yang,

Affiliations Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China, Hubei Clinical and Research Center of Thrombosis and Hemostasis, Wuhan, Hubei, People's Republic of China, Targeted Biotherapy Key Laboratory of Ministry of Education, Wuhan, Hubei, People's Republic of China
⨯
Heng Mei,

Affiliations Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China, Hubei Clinical and Research Center of Thrombosis and Hemostasis, Wuhan, Hubei, People's Republic of China, Targeted Biotherapy Key Laboratory of Ministry of Education, Wuhan, Hubei, People's Republic of China
⨯
Huafang Wang,

Affiliations Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China, Hubei Clinical and Research Center of Thrombosis and Hemostasis, Wuhan, Hubei, People's Republic of China, Targeted Biotherapy Key Laboratory of Ministry of Education, Wuhan, Hubei, People's Republic of China
⨯
Xuan Lu,

Affiliations Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China, Hubei Clinical and Research Center of Thrombosis and Hemostasis, Wuhan, Hubei, People's Republic of China, Targeted Biotherapy Key Laboratory of Ministry of Education, Wuhan, Hubei, People's Republic of China
⨯
Jianming Yu,

Affiliations Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China, Hubei Clinical and Research Center of Thrombosis and Hemostasis, Wuhan, Hubei, People's Republic of China, Targeted Biotherapy Key Laboratory of Ministry of Education, Wuhan, Hubei, People's Republic of China
⨯
Qingyun Wang,

Affiliations Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China, Hubei Clinical and Research Center of Thrombosis and Hemostasis, Wuhan, Hubei, People's Republic of China, Targeted Biotherapy Key Laboratory of Ministry of Education, Wuhan, Hubei, People's Republic of China
⨯
Yu Hu

* E-mail: dr_huyu@126.com

Affiliations Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China, Hubei Clinical and Research Center of Thrombosis and Hemostasis, Wuhan, Hubei, People's Republic of China, Targeted Biotherapy Key Laboratory of Ministry of Education, Wuhan, Hubei, People's Republic of China
⨯

Genetic Background Analysis of Protein C Deficiency Demonstrates a Recurrent Mutation Associated with Venous Thrombosis in Chinese Population

Liang Tang,
Tao Guo,
Rui Yang,
Heng Mei,
Huafang Wang,
Xuan Lu,
Jianming Yu,
Qingyun Wang,
Yu Hu

Published: April 24, 2012
https://doi.org/10.1371/journal.pone.0035773

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Thrombosis
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Protein C deficiency
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Deep vein thrombosis
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Frameshift mutation
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