PAI-1-Dependent Endothelial Cell Death Determines Severity of Radiation-Induced Intestinal Injury

Rym Abderrahmani; Agnes François; Valerie Buard; Georges Tarlet; Karl Blirando; Mohammad Hneino; Aurelie Vaurijoux; Marc Benderitter; Jean-Christophe Sabourin; Fabien Milliat

doi:10.1371/journal.pone.0035740

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Peer-reviewed

Research Article

PAI-1-Dependent Endothelial Cell Death Determines Severity of Radiation-Induced Intestinal Injury

Rym Abderrahmani,

Affiliation Laboratory of Radiopathology and Experimental Therapeutics, Institute for Radiological Protection and Nuclear Safety, Fontenay-aux-Roses, France
⨯
Agnes François,

Affiliation Laboratory of Radiopathology and Experimental Therapeutics, Institute for Radiological Protection and Nuclear Safety, Fontenay-aux-Roses, France
⨯
Valerie Buard,

Affiliation Laboratory of Radiopathology and Experimental Therapeutics, Institute for Radiological Protection and Nuclear Safety, Fontenay-aux-Roses, France
⨯
Georges Tarlet,

Affiliation Laboratory of Radiopathology and Experimental Therapeutics, Institute for Radiological Protection and Nuclear Safety, Fontenay-aux-Roses, France
⨯
Karl Blirando,

Affiliation Laboratory of Radiopathology and Experimental Therapeutics, Institute for Radiological Protection and Nuclear Safety, Fontenay-aux-Roses, France
⨯
Mohammad Hneino,

Affiliation Laboratory of Radiopathology and Experimental Therapeutics, Institute for Radiological Protection and Nuclear Safety, Fontenay-aux-Roses, France
⨯
Aurelie Vaurijoux,

Affiliation Laboratory of Biological Dosimetry, Institute for Radiological Protection and Nuclear Safety, Fontenay-aux-Roses, France
⨯
Marc Benderitter,

Affiliation Laboratory of Radiopathology and Experimental Therapeutics, Institute for Radiological Protection and Nuclear Safety, Fontenay-aux-Roses, France
⨯
Jean-Christophe Sabourin,

Affiliation Department of Pathology, Rouen University Hospital, Rouen, France
⨯
Fabien Milliat

* E-mail: fabien.milliat@irsn.fr

Affiliation Laboratory of Radiopathology and Experimental Therapeutics, Institute for Radiological Protection and Nuclear Safety, Fontenay-aux-Roses, France
⨯

PAI-1-Dependent Endothelial Cell Death Determines Severity of Radiation-Induced Intestinal Injury

Rym Abderrahmani,
Agnes François,
Valerie Buard,
Georges Tarlet,
Karl Blirando,
Mohammad Hneino,
Aurelie Vaurijoux,
Marc Benderitter,
Jean-Christophe Sabourin,
Fabien Milliat

Published: April 26, 2012
https://doi.org/10.1371/journal.pone.0035740

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Endothelial cells
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DAPI staining
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