E3 Ligase Activity of XIAP RING Domain Is Required for XIAP-Mediated Cancer Cell Migration, but Not for Its RhoGDI Binding Activity

Jinyi Liu; Dongyun Zhang; Wenjing Luo; Jianxiu Yu; Jingxia Li; Yonghui Yu; Xinhai Zhang; Jingyuan Chen; Xue-Ru Wu; Chuanshu Huang

doi:10.1371/journal.pone.0035682

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Peer-reviewed

Research Article

E3 Ligase Activity of XIAP RING Domain Is Required for XIAP-Mediated Cancer Cell Migration, but Not for Its RhoGDI Binding Activity

Jinyi Liu ,

Contributed equally to this work with: Jinyi Liu, Dongyun Zhang, Wenjing Luo

Affiliation Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York, United States of America
⨯
Dongyun Zhang ,

Contributed equally to this work with: Jinyi Liu, Dongyun Zhang, Wenjing Luo

Affiliation Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York, United States of America
⨯
Wenjing Luo ,

Contributed equally to this work with: Jinyi Liu, Dongyun Zhang, Wenjing Luo

Affiliation Department of Occupational and Environmental Health Sciences, Fourth Military Medical University, Xi'an, Shanxi, China
⨯
Jianxiu Yu,

Affiliation Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York, United States of America
⨯
Jingxia Li,

Affiliation Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York, United States of America
⨯
Yonghui Yu,

Affiliation Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York, United States of America
⨯
Xinhai Zhang,

Affiliation Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York, United States of America
⨯
Jingyuan Chen,

Affiliation Department of Occupational and Environmental Health Sciences, Fourth Military Medical University, Xi'an, Shanxi, China
⨯
Xue-Ru Wu,

Affiliation Departments of Urology and Pathology, New York University School of Medicine, Tuxedo, New York, United States of America
⨯
Chuanshu Huang

* E-mail: chuanshu.huang@ nyumc.org

Affiliation Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York, United States of America
⨯

E3 Ligase Activity of XIAP RING Domain Is Required for XIAP-Mediated Cancer Cell Migration, but Not for Its RhoGDI Binding Activity

Jinyi Liu,
Dongyun Zhang,
Wenjing Luo,
Jianxiu Yu,
Jingxia Li,
Yonghui Yu,
Xinhai Zhang,
Jingyuan Chen,
Xue-Ru Wu,
Chuanshu Huang

Published: April 19, 2012
https://doi.org/10.1371/journal.pone.0035682

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Transfection
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Ligases
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Cell migration
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Actin polymerization
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Cancer cell migration
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