Functional Implications of Novel Human Acid Sphingomyelinase Splice Variants

Cosima Rhein; Philipp Tripal; Angela Seebahn; Alice Konrad; Marcel Kramer; Christine Nagel; Jonas Kemper; Jens Bode; Christiane Mühle; Erich Gulbins; Martin Reichel; Cord-Michael Becker; Johannes Kornhuber

doi:10.1371/journal.pone.0035467

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Open Access

Peer-reviewed

Research Article

Functional Implications of Novel Human Acid Sphingomyelinase Splice Variants

Cosima Rhein,

Affiliation Department of Psychiatry and Psychotherapy, University Hospital, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany
⨯
Philipp Tripal,

Affiliation Department of Psychiatry and Psychotherapy, University Hospital, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany
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Angela Seebahn,

Affiliation Institute of Biochemistry, Emil-Fischer-Centre, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany
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Alice Konrad,

Affiliation Department of Psychiatry and Psychotherapy, University Hospital, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany
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Marcel Kramer,

Affiliation Leibniz Institute for Age Research – Fritz Lipmann Institute and Center for Sepsis Control and Care at Jena University Hospital, Jena, Germany
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Christine Nagel,

Affiliation Department of Psychiatry and Psychotherapy, University Hospital, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany
⨯
Jonas Kemper,

Affiliation Department of Psychiatry and Psychotherapy, University Hospital, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany
⨯
Jens Bode,

Affiliation Department of Psychiatry and Psychotherapy, University Hospital, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany
⨯
Christiane Mühle,

Affiliation Department of Psychiatry and Psychotherapy, University Hospital, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany
⨯
Erich Gulbins,

Affiliation Department of Molecular Biology, University of Duisburg-Essen, Essen, Germany
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Martin Reichel,

Affiliation Department of Psychiatry and Psychotherapy, University Hospital, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany
⨯
Cord-Michael Becker,

Affiliation Institute of Biochemistry, Emil-Fischer-Centre, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany
⨯
Johannes Kornhuber

* E-mail: Johannes.Kornhuber@uk-erlangen.de

Affiliation Department of Psychiatry and Psychotherapy, University Hospital, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany
⨯

Functional Implications of Novel Human Acid Sphingomyelinase Splice Variants

Cosima Rhein,
Philipp Tripal,
Angela Seebahn,
Alice Konrad,
Marcel Kramer,
Christine Nagel,
Jonas Kemper,
Jens Bode,
Christiane Mühle,
Erich Gulbins

Published: April 27, 2012
https://doi.org/10.1371/journal.pone.0035467

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Alternative splicing
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Blood cells
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Transfection
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Introns
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Oligonucleotides
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Polymerase chain reaction
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Protein domains
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Coding mechanisms
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