Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus

Chien-Te Tseng; Elena Sbrana; Naoko Iwata-Yoshikawa; Patrick C. Newman; Tania Garron; Robert L. Atmar; Clarence J. Peters; Robert B. Couch

doi:10.1371/journal.pone.0035421

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Peer-reviewed

Research Article

Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus

Chien-Te Tseng,

Affiliations Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas, United States of America, Center for Biodefense and Emerging Disease, The University of Texas Medical Branch, Galveston, Texas, United States of America
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Elena Sbrana,

Affiliation Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas, United States of America
⨯
Naoko Iwata-Yoshikawa,

Affiliations Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas, United States of America, Center for Biodefense and Emerging Disease, The University of Texas Medical Branch, Galveston, Texas, United States of America
⨯
Patrick C. Newman,

Affiliation Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas, United States of America
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Tania Garron,

Affiliation Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas, United States of America
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Robert L. Atmar,

Affiliations Department of Medicine, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America
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Clarence J. Peters,

Affiliations Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas, United States of America, Center for Biodefense and Emerging Disease, The University of Texas Medical Branch, Galveston, Texas, United States of America
⨯
Robert B. Couch

* E-mail: rcouch@bcm.edu

Affiliations Department of Medicine, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America
⨯

Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus

Chien-Te Tseng,
Elena Sbrana,
Naoko Iwata-Yoshikawa,
Patrick C. Newman,
Tania Garron,
Robert L. Atmar,
Clarence J. Peters,
Robert B. Couch

Published: April 20, 2012
https://doi.org/10.1371/journal.pone.0035421

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