Simultaneous Disruption of Mouse ASIC1a, ASIC2 and ASIC3 Genes Enhances Cutaneous Mechanosensitivity

Sinyoung Kang; Jun Ho Jang; Margaret P. Price; Mamta Gautam; Christopher J. Benson; Huiyu Gong; Michael J. Welsh; Timothy J. Brennan

doi:10.1371/journal.pone.0035225

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Peer-reviewed

Research Article

Simultaneous Disruption of Mouse ASIC1a, ASIC2 and ASIC3 Genes Enhances Cutaneous Mechanosensitivity

Sinyoung Kang,

Affiliation Department of Anesthesia, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
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Jun Ho Jang,

Affiliation Department of Anesthesia, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
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Margaret P. Price,

Affiliation Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
⨯
Mamta Gautam,

Affiliation Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
⨯
Christopher J. Benson,

Affiliations Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America, Department of Molecular Physiology and Biophysics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
⨯
Huiyu Gong,

Affiliation Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
⨯
Michael J. Welsh,

Affiliations Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America, Department of Molecular Physiology and Biophysics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America, Howard Hughes Medical Institute, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America
⨯
Timothy J. Brennan

* E-mail: tim-brennan@uiowa.edu

Affiliations Department of Anesthesia, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America, Department of Pharmacology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America
⨯

Simultaneous Disruption of Mouse ASIC1a, ASIC2 and ASIC3 Genes Enhances Cutaneous Mechanosensitivity

Sinyoung Kang,
Jun Ho Jang,
Margaret P. Price,
Mamta Gautam,
Christopher J. Benson,
Huiyu Gong,
Michael J. Welsh,
Timothy J. Brennan

Published: April 10, 2012
https://doi.org/10.1371/journal.pone.0035225

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