Development of a Tetrameric Streptavidin Mutein with Reversible Biotin Binding Capability: Engineering a Mobile Loop as an Exit Door for Biotin

• Valerie J. O'Sullivan,

  Affiliation Thermo Fisher Scientific, Inc., Pierce Protein Research, Rockford, Illinois, United States of America

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• Isabelle Barrette-Ng,

  Affiliation Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada

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• Eric Hommema,

  Affiliation Thermo Fisher Scientific, Inc., Pierce Protein Research, Rockford, Illinois, United States of America

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• Greg T. Hermanson,

  Affiliation Thermo Fisher Scientific, Inc., Pierce Protein Research, Rockford, Illinois, United States of America

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• Mark Schofield,

  Current address: Pall Life Sciences, Northborough, Massachusetts, United States of America

  Affiliation Thermo Fisher Scientific, Inc., Pierce Protein Research, Rockford, Illinois, United States of America

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• Sau-Ching Wu,

  Affiliation Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada

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• Claudia Honetschlaeger,

  Affiliation Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada

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• Kenneth K.-S. Ng,

  Affiliation Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada

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• Sui-Lam Wong

  * E-mail: slwong@ucalgary.ca

  Affiliation Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada

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