Dynamics of Hepatitis B Virus Quasispecies in Association with Nucleos(t)ide Analogue Treatment Determined by Ultra-Deep Sequencing

Norihiro Nishijima; Hiroyuki Marusawa; Yoshihide Ueda; Ken Takahashi; Akihiro Nasu; Yukio Osaki; Tadayuki Kou; Shujiro Yazumi; Takeshi Fujiwara; Soken Tsuchiya; Kazuharu Shimizu; Shinji Uemoto; Tsutomu Chiba

doi:10.1371/journal.pone.0035052

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Open Access

Peer-reviewed

Research Article

Dynamics of Hepatitis B Virus Quasispecies in Association with Nucleos(t)ide Analogue Treatment Determined by Ultra-Deep Sequencing

Norihiro Nishijima,

Affiliation Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
⨯
Hiroyuki Marusawa ,

* E-mail: maru@kuhp.kyoto-u.ac.jp

Affiliation Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
⨯
Yoshihide Ueda,

Affiliation Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
⨯
Ken Takahashi,

Affiliation Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
⨯
Akihiro Nasu,

Affiliation Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
⨯
Yukio Osaki,

Affiliation Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Osaka, Japan
⨯
Tadayuki Kou,

Affiliation Department of Gastroenterology and Hepatology, Tazuke Kofukai Medical Research Institute, Kitano Hospital, Osaka, Japan
⨯
Shujiro Yazumi,

Affiliation Department of Gastroenterology and Hepatology, Tazuke Kofukai Medical Research Institute, Kitano Hospital, Osaka, Japan
⨯
Takeshi Fujiwara,

Affiliation Department of Nanobio Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
⨯
Soken Tsuchiya,

Affiliation Department of Nanobio Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
⨯
Kazuharu Shimizu,

Affiliation Department of Nanobio Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
⨯
Shinji Uemoto,

Affiliation Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
⨯
Tsutomu Chiba

Affiliation Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
⨯

Dynamics of Hepatitis B Virus Quasispecies in Association with Nucleos(t)ide Analogue Treatment Determined by Ultra-Deep Sequencing

Norihiro Nishijima,
Hiroyuki Marusawa,
Yoshihide Ueda,
Ken Takahashi,
Akihiro Nasu,
Yukio Osaki,
Tadayuki Kou,
Shujiro Yazumi,
Takeshi Fujiwara,
Soken Tsuchiya

Published: April 16, 2012
https://doi.org/10.1371/journal.pone.0035052

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