RAGE Mediates Accelerated Diabetic Vein Graft Atherosclerosis Induced by Combined Mechanical Stress and AGEs via Synergistic ERK Activation

Yuhuang Li; Shuying Liu; Zhengyu Zhang; Qingbo Xu; Fukang Xie; Jingjing Wang; Suning Ping; Chen Li; Zhaojing Wang; Min Zhang; Jintao Huang; Dadi Chen; Liping Hu; Chaohong Li

doi:10.1371/journal.pone.0035016

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Open Access

Peer-reviewed

Research Article

RAGE Mediates Accelerated Diabetic Vein Graft Atherosclerosis Induced by Combined Mechanical Stress and AGEs via Synergistic ERK Activation

Yuhuang Li ,

Contributed equally to this work with: Yuhuang Li, Shuying Liu

Affiliation Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
⨯
Shuying Liu ,

Contributed equally to this work with: Yuhuang Li, Shuying Liu

Affiliation Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
⨯
Zhengyu Zhang,

Affiliation Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
⨯
Qingbo Xu,

Affiliation Cardiovascular Division, King's College London British Heart Foundation Centre, London, United Kingdom
⨯
Fukang Xie,

Affiliation Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
⨯
Jingjing Wang,

Affiliation Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
⨯
Suning Ping,

Affiliation Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
⨯
Chen Li,

Affiliation Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
⨯
Zhaojing Wang,

Affiliation Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
⨯
Min Zhang,

Affiliation Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
⨯
Jintao Huang,

Affiliation Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
⨯
Dadi Chen,

Affiliation Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
⨯
Liping Hu,

Affiliation Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
⨯
Chaohong Li

* E-mail: lichaohongzq@yahoo.com (CHL)

Affiliation Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
⨯

RAGE Mediates Accelerated Diabetic Vein Graft Atherosclerosis Induced by Combined Mechanical Stress and AGEs via Synergistic ERK Activation

Yuhuang Li,
Shuying Liu,
Zhengyu Zhang,
Qingbo Xu,
Fukang Xie,
Jingjing Wang,
Suning Ping,
Chen Li,
Zhaojing Wang,
Min Zhang

Published: April 9, 2012
https://doi.org/10.1371/journal.pone.0035016

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Veins
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Diabetes mellitus
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ERK signaling cascade
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DAPI staining
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