The Immune Response to Melanoma Is Limited by Thymic Selection of Self-Antigens

Ulrike Träger; Sophie Sierro; Gordana Djordjevic; Basma Bouzo; Shivani Khandwala; Antonella Meloni; Monika Mortensen; Anna Katharina Simon

doi:10.1371/journal.pone.0035005

Loading metrics

Open Access

Peer-reviewed

Research Article

The Immune Response to Melanoma Is Limited by Thymic Selection of Self-Antigens

Ulrike Träger,

Affiliations MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, NIHR Biomedical Centre, Oxford, United Kingdom
⨯
Sophie Sierro,

Affiliation Ludwig Institute for Cancer Research, Epalinges, Switzerland
⨯
Gordana Djordjevic,

Affiliations MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, NIHR Biomedical Centre, Oxford, United Kingdom
⨯
Basma Bouzo,

Affiliations MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, NIHR Biomedical Centre, Oxford, United Kingdom
⨯
Shivani Khandwala,

Affiliations MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, NIHR Biomedical Centre, Oxford, United Kingdom
⨯
Antonella Meloni,

Affiliation Pediatric Clinic II, Ospedale Microcitemico and Department of Biomedical and Biotechnological Science, University of Cagliari, Cagliari, Italy
⨯
Monika Mortensen,

Affiliations MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, NIHR Biomedical Centre, Oxford, United Kingdom, Apoptosis Department and Center for Genotoxic Stress Research, Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark
⨯
Anna Katharina Simon

* E-mail: katja.simon@ndm.ox.ac.uk

Affiliations MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, NIHR Biomedical Centre, Oxford, United Kingdom
⨯

The Immune Response to Melanoma Is Limited by Thymic Selection of Self-Antigens

Ulrike Träger,
Sophie Sierro,
Gordana Djordjevic,
Basma Bouzo,
Shivani Khandwala,
Antonella Meloni,
Monika Mortensen,
Anna Katharina Simon

Published: April 10, 2012
https://doi.org/10.1371/journal.pone.0035005

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

T cells
Is the Subject Area "T cells" applicable to this article?

Thanks for your feedback.
Cancers and neoplasms
Is the Subject Area "Cancers and neoplasms" applicable to this article?

Thanks for your feedback.
Cytotoxic T cells
Is the Subject Area "Cytotoxic T cells" applicable to this article?

Thanks for your feedback.
Lung and intrathoracic tumors
Is the Subject Area "Lung and intrathoracic tumors" applicable to this article?

Thanks for your feedback.
Melanoma
Is the Subject Area "Melanoma" applicable to this article?

Thanks for your feedback.
Regulatory T cells
Is the Subject Area "Regulatory T cells" applicable to this article?

Thanks for your feedback.
Melanocytes
Is the Subject Area "Melanocytes" applicable to this article?

Thanks for your feedback.
Cutaneous melanoma
Is the Subject Area "Cutaneous melanoma" applicable to this article?

Thanks for your feedback.