Lestaurtinib Inhibits Histone Phosphorylation and Androgen-Dependent Gene Expression in Prostate Cancer Cells

Jens Köhler; German Erlenkamp; Adrien Eberlin; Tobias Rumpf; Inna Slynko; Eric Metzger; Roland Schüle; Wolfgang Sippl; Manfred Jung

doi:10.1371/journal.pone.0034973

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Peer-reviewed

Research Article

Lestaurtinib Inhibits Histone Phosphorylation and Androgen-Dependent Gene Expression in Prostate Cancer Cells

Jens Köhler,

Current address: Westfälische Wilhelms-University Münster, Institute of Pharmaceutical and Medicinal Chemistry, Münster, Germany

Affiliation Albert-Ludwigs-University Freiburg, Institute of Pharmaceutical Sciences, Albertstrasse, Freiburg, Germany
⨯
German Erlenkamp,

Affiliation Department of Pharmaceutical Chemistry, Martin-Luther University of Halle-Wittenberg, Halle/Saale, Germany
⨯
Adrien Eberlin,

Affiliation Department of Urology/Women's Hospital and Center for Clinical Research, University of Freiburg Medical Center, Freiburg, Germany
⨯
Tobias Rumpf,

Affiliation Albert-Ludwigs-University Freiburg, Institute of Pharmaceutical Sciences, Albertstrasse, Freiburg, Germany
⨯
Inna Slynko,

Affiliation Department of Pharmaceutical Chemistry, Martin-Luther University of Halle-Wittenberg, Halle/Saale, Germany
⨯
Eric Metzger,

Affiliation Department of Urology/Women's Hospital and Center for Clinical Research, University of Freiburg Medical Center, Freiburg, Germany
⨯
Roland Schüle,

Affiliation Department of Urology/Women's Hospital and Center for Clinical Research, University of Freiburg Medical Center, Freiburg, Germany
⨯
Wolfgang Sippl,

Current address: Freiburg Institute of Advanced Studies, University Freiburg, Freiburg, Deutschland

Affiliation Department of Pharmaceutical Chemistry, Martin-Luther University of Halle-Wittenberg, Halle/Saale, Germany
⨯
Manfred Jung

* E-mail: manfred.jung@pharmazie.uni-freiburg.de

Current address: Freiburg Institute of Advanced Studies, University Freiburg, Freiburg, Deutschland

Affiliation Albert-Ludwigs-University Freiburg, Institute of Pharmaceutical Sciences, Albertstrasse, Freiburg, Germany
⨯

Lestaurtinib Inhibits Histone Phosphorylation and Androgen-Dependent Gene Expression in Prostate Cancer Cells

Jens Köhler,
German Erlenkamp,
Adrien Eberlin,
Tobias Rumpf,
Inna Slynko,
Eric Metzger,
Roland Schüle,
Wolfgang Sippl,
Manfred Jung

Published: April 20, 2012
https://doi.org/10.1371/journal.pone.0034973

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Androgens
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Histones
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Kinase inhibitors
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Molecular dynamics
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Hydrogen bonding
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Epigenetics
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Gene expression
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Prostate cancer
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