Modulation of Astrocytic Mitochondrial Function by Dichloroacetate Improves Survival and Motor Performance in Inherited Amyotrophic Lateral Sclerosis

Ernesto Miquel; Adriana Cassina; Laura Martínez-Palma; Carmen Bolatto; Emiliano Trías; Mandi Gandelman; Rafael Radi; Luis Barbeito; Patricia Cassina

doi:10.1371/journal.pone.0034776

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Peer-reviewed

Research Article

Modulation of Astrocytic Mitochondrial Function by Dichloroacetate Improves Survival and Motor Performance in Inherited Amyotrophic Lateral Sclerosis

Ernesto Miquel ,

Contributed equally to this work with: Ernesto Miquel, Adriana Cassina

Affiliation Departamento de Histología y Embriología, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay
⨯
Adriana Cassina ,

Contributed equally to this work with: Ernesto Miquel, Adriana Cassina

Affiliations Departamento de Bioquímica, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay, CEINBIO, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay
⨯
Laura Martínez-Palma,

Affiliation Departamento de Histología y Embriología, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay
⨯
Carmen Bolatto,

Affiliation Departamento de Histología y Embriología, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay
⨯
Emiliano Trías,

Affiliation Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay
⨯
Mandi Gandelman,

Affiliation Departamento de Histología y Embriología, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay
⨯
Rafael Radi,

Affiliations Departamento de Bioquímica, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay, CEINBIO, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay
⨯
Luis Barbeito,

Affiliations Institut Pasteur de Montevideo, Montevideo, Uruguay, CEINBIO, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay
⨯
Patricia Cassina

* E-mail: pcassina@fmed.edu.uy

Affiliations Departamento de Histología y Embriología, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay, CEINBIO, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay
⨯

Modulation of Astrocytic Mitochondrial Function by Dichloroacetate Improves Survival and Motor Performance in Inherited Amyotrophic Lateral Sclerosis

Ernesto Miquel,
Adriana Cassina,
Laura Martínez-Palma,
Carmen Bolatto,
Emiliano Trías,
Mandi Gandelman,
Rafael Radi,
Luis Barbeito,
Patricia Cassina

Published: April 3, 2012
https://doi.org/10.1371/journal.pone.0034776

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