Contribution of Efflux to the Emergence of Isoniazid and Multidrug Resistance in Mycobacterium tuberculosis

Diana Machado; Isabel Couto; João Perdigão; Liliana Rodrigues; Isabel Portugal; Pedro Baptista; Bruno Veigas; Leonard Amaral; Miguel Viveiros

doi:10.1371/journal.pone.0034538

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Peer-reviewed

Research Article

Contribution of Efflux to the Emergence of Isoniazid and Multidrug Resistance in Mycobacterium tuberculosis

Diana Machado,

Affiliation Grupo de Micobactérias, Unidade de Microbiologia Médica, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT/UNL), Lisboa, Portugal
⨯
Isabel Couto,

Affiliations Grupo de Micobactérias, Unidade de Microbiologia Médica, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT/UNL), Lisboa, Portugal, Centro de Recursos Microbiológicos (CREM), Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal
⨯
João Perdigão,

Affiliation Centro de Patogénese Molecular/URIA, Faculdade de Farmácia, Universidade de Lisboa, Lisboa, Portugal
⨯
Liliana Rodrigues,

Affiliation Grupo de Micobactérias, Unidade de Microbiologia Médica, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT/UNL), Lisboa, Portugal
⨯
Isabel Portugal,

Affiliation Centro de Patogénese Molecular/URIA, Faculdade de Farmácia, Universidade de Lisboa, Lisboa, Portugal
⨯
Pedro Baptista,

Affiliation CIGMH, Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal
⨯
Bruno Veigas,

Affiliation CIGMH, Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal
⨯
Leonard Amaral,

Affiliations Grupo de Micobactérias, Unidade de Microbiologia Médica, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT/UNL), Lisboa, Portugal, COST ACTION BM0701 (ATENS), Brusells, Belgium
⨯
Miguel Viveiros

* E-mail: mviveiros@ihmt.unl.pt

Affiliations Grupo de Micobactérias, Unidade de Microbiologia Médica, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT/UNL), Lisboa, Portugal, COST ACTION BM0701 (ATENS), Brusells, Belgium
⨯

Contribution of Efflux to the Emergence of Isoniazid and Multidrug Resistance in Mycobacterium tuberculosis

Diana Machado,
Isabel Couto,
João Perdigão,
Liliana Rodrigues,
Isabel Portugal,
Pedro Baptista,
Bruno Veigas,
Leonard Amaral,
Miguel Viveiros

Published: April 6, 2012
https://doi.org/10.1371/journal.pone.0034538

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Antibiotic resistance
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Isoniazid
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Mycobacterium tuberculosis
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Antibiotics
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Gene expression
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Point mutation
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Chlorpromazine
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Multi-drug-resistant tuberculosis
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