The 5HT1a Receptor Agonist 8-Oh DPAT Induces Protection from Lipofuscin Accumulation and Oxidative Stress in the Retinal Pigment Epithelium

Prajitha Thampi; Haripriya Vittal Rao; Sayak K. Mitter; Jun Cai; Haoyu Mao; Hong Li; Soojung Seo; Xiaoping Qi; Alfred S. Lewin; Carl Romano; Michael E. Boulton

doi:10.1371/journal.pone.0034468

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Peer-reviewed

Research Article

The 5HT_1a Receptor Agonist 8-Oh DPAT Induces Protection from Lipofuscin Accumulation and Oxidative Stress in the Retinal Pigment Epithelium

Prajitha Thampi,

Affiliation Department of Anatomy and Cell Biology, University of Florida, Gainesville, Florida, United States of America
⨯
Haripriya Vittal Rao,

Affiliation Department of Anatomy and Cell Biology, University of Florida, Gainesville, Florida, United States of America
⨯
Sayak K. Mitter,

Affiliation Department of Anatomy and Cell Biology, University of Florida, Gainesville, Florida, United States of America
⨯
Jun Cai,

Affiliation Department of Anatomy and Cell Biology, University of Florida, Gainesville, Florida, United States of America
⨯
Haoyu Mao,

Affiliation Department of Molecular Genetics & Microbiology, University of Florida, Gainesville, Florida, United States of America
⨯
Hong Li,

Affiliation Department of Molecular Genetics & Microbiology, University of Florida, Gainesville, Florida, United States of America
⨯
Soojung Seo,

Affiliation Department of Molecular Genetics & Microbiology, University of Florida, Gainesville, Florida, United States of America
⨯
Xiaoping Qi,

Affiliation Department of Anatomy and Cell Biology, University of Florida, Gainesville, Florida, United States of America
⨯
Alfred S. Lewin,

Affiliation Department of Molecular Genetics & Microbiology, University of Florida, Gainesville, Florida, United States of America
⨯
Carl Romano,

Affiliation Retina Research, Alcon Laboratories, Inc, Fort Worth, Texas, United States of America
⨯
Michael E. Boulton

* E-mail: meboulton@ufl.edu

Affiliation Department of Anatomy and Cell Biology, University of Florida, Gainesville, Florida, United States of America
⨯

The 5HT_1a Receptor Agonist 8-Oh DPAT Induces Protection from Lipofuscin Accumulation and Oxidative Stress in the Retinal Pigment Epithelium

Prajitha Thampi,
Haripriya Vittal Rao,
Sayak K. Mitter,
Jun Cai,
Haoyu Mao,
Hong Li,
Soojung Seo,
Xiaoping Qi,
Alfred S. Lewin,
Carl Romano

Published: April 3, 2012
https://doi.org/10.1371/journal.pone.0034468

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