Outside-In Signalling Generated by a Constitutively Activated Integrin αIIbβ3 Impairs Proplatelet Formation in Human Megakaryocytes

Open Access

Peer-reviewed

Research Article

Outside-In Signalling Generated by a Constitutively Activated Integrin α_IIbβ₃ Impairs Proplatelet Formation in Human Megakaryocytes

Loredana Bury,

Affiliations Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Perugia, Italy, Biotechnology Laboratories, Department of Biochemistry, University of Pavia, IRCCS San Matteo Foundation, Pavia, Italy
⨯
Alessandro Malara,

Affiliations Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Perugia, Italy, Biotechnology Laboratories, Department of Biochemistry, University of Pavia, IRCCS San Matteo Foundation, Pavia, Italy
⨯
Paolo Gresele ,

* E-mail: grespa@unipg.it

Affiliation Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Perugia, Italy
⨯
Alessandra Balduini

Affiliation Biotechnology Laboratories, Department of Biochemistry, University of Pavia, IRCCS San Matteo Foundation, Pavia, Italy
⨯

Megakaryocytes
Is the Subject Area "Megakaryocytes" applicable to this article?

Thanks for your feedback.
Platelets
Is the Subject Area "Platelets" applicable to this article?

Thanks for your feedback.
Fibrinogen
Is the Subject Area "Fibrinogen" applicable to this article?

Thanks for your feedback.
Integrins
Is the Subject Area "Integrins" applicable to this article?

Thanks for your feedback.
Actins
Is the Subject Area "Actins" applicable to this article?

Thanks for your feedback.
Platelet activation
Is the Subject Area "Platelet activation" applicable to this article?

Thanks for your feedback.
Cell differentiation
Is the Subject Area "Cell differentiation" applicable to this article?

Thanks for your feedback.
Flow cytometry
Is the Subject Area "Flow cytometry" applicable to this article?

Thanks for your feedback.