Internalization of Modified Lipids by CD36 and SR-A Leads to Hepatic Inflammation and Lysosomal Cholesterol Storage in Kupffer Cells

Veerle Bieghs; Fons Verheyen; Patrick J. van Gorp; Tim Hendrikx; Kristiaan Wouters; Dieter Lütjohann; Marion J. J. Gijbels; Maria Febbraio; Christoph J. Binder; Marten H. Hofker; Ronit Shiri-Sverdlov

doi:10.1371/journal.pone.0034378

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Open Access

Peer-reviewed

Research Article

Internalization of Modified Lipids by CD36 and SR-A Leads to Hepatic Inflammation and Lysosomal Cholesterol Storage in Kupffer Cells

Veerle Bieghs,

Affiliation Department of Molecular Genetics, Electron Microscopy Unit of Molecular Cell Biology, and Pathology, Nutrition and Toxicology Research (NUTRIM) and Cardiovascular Research (CARIM) Institutes of Maastricht, University of Maastricht, Maastricht, The Netherlands
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Fons Verheyen,

Affiliation Department of Molecular Genetics, Electron Microscopy Unit of Molecular Cell Biology, and Pathology, Nutrition and Toxicology Research (NUTRIM) and Cardiovascular Research (CARIM) Institutes of Maastricht, University of Maastricht, Maastricht, The Netherlands
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Patrick J. van Gorp,

Affiliation Department of Molecular Genetics, Electron Microscopy Unit of Molecular Cell Biology, and Pathology, Nutrition and Toxicology Research (NUTRIM) and Cardiovascular Research (CARIM) Institutes of Maastricht, University of Maastricht, Maastricht, The Netherlands
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Tim Hendrikx,

Affiliation Department of Molecular Genetics, Electron Microscopy Unit of Molecular Cell Biology, and Pathology, Nutrition and Toxicology Research (NUTRIM) and Cardiovascular Research (CARIM) Institutes of Maastricht, University of Maastricht, Maastricht, The Netherlands
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Kristiaan Wouters,

Affiliation Inserm U1011, UDSL, Institut Pasteur de Lille, University Lille Nord de France, Lille, France
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Dieter Lütjohann,

Affiliation Institute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Bonn, Germany
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Marion J. J. Gijbels,

Affiliation Department of Molecular Genetics, Electron Microscopy Unit of Molecular Cell Biology, and Pathology, Nutrition and Toxicology Research (NUTRIM) and Cardiovascular Research (CARIM) Institutes of Maastricht, University of Maastricht, Maastricht, The Netherlands
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Maria Febbraio,

Affiliation Department of Molecular Cardiology, Lerner Research Institute, Cleveland, Ohio, United States of America
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Christoph J. Binder,

Affiliation Center for Molecular Medicine, Austrian Academy of Sciences, and Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria
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Marten H. Hofker,

Affiliation Department of Pathology & Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
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Ronit Shiri-Sverdlov

* E-mail: r.sverdlov@maastrichtuniversity.nl

Affiliation Department of Molecular Genetics, Electron Microscopy Unit of Molecular Cell Biology, and Pathology, Nutrition and Toxicology Research (NUTRIM) and Cardiovascular Research (CARIM) Institutes of Maastricht, University of Maastricht, Maastricht, The Netherlands
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Internalization of Modified Lipids by CD36 and SR-A Leads to Hepatic Inflammation and Lysosomal Cholesterol Storage in Kupffer Cells

Veerle Bieghs,
Fons Verheyen,
Patrick J. van Gorp,
Tim Hendrikx,
Kristiaan Wouters,
Dieter Lütjohann,
Marion J. J. Gijbels,
Maria Febbraio,
Christoph J. Binder,
Marten H. Hofker

Published: March 28, 2012
https://doi.org/10.1371/journal.pone.0034378

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