JKA97, a Novel Benzylidene Analog of Harmine, Exerts Anti-Cancer Effects by Inducing G1 Arrest, Apoptosis, and p53-Independent Up-Regulation of p21

Xinyi Yang; Wei Wang; Jiang-Jiang Qin; Ming-Hai Wang; Horrick Sharma; John K. Buolamwini; Hui Wang; Ruiwen Zhang

doi:10.1371/journal.pone.0034303

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Research Article

JKA97, a Novel Benzylidene Analog of Harmine, Exerts Anti-Cancer Effects by Inducing G1 Arrest, Apoptosis, and p53-Independent Up-Regulation of p21

Xinyi Yang ,

Contributed equally to this work with: Xinyi Yang, Wei Wang

Affiliation Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas, United States of America
⨯
Wei Wang ,

Contributed equally to this work with: Xinyi Yang, Wei Wang

Affiliations Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas, United States of America, Cancer Biology Center, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas, United States of America
⨯
Jiang-Jiang Qin,

Affiliation Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas, United States of America
⨯
Ming-Hai Wang,

Affiliations Cancer Biology Center, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas, United States of America, Department of Biomedical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas, United States of America
⨯
Horrick Sharma,

Affiliation Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
⨯
John K. Buolamwini,

Affiliation Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
⨯
Hui Wang,

Affiliation Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
⨯
Ruiwen Zhang

* E-mail: ruiwen.zhang@ttuhsc.edu

Affiliations Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas, United States of America, Cancer Biology Center, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas, United States of America
⨯

JKA97, a Novel Benzylidene Analog of Harmine, Exerts Anti-Cancer Effects by Inducing G1 Arrest, Apoptosis, and p53-Independent Up-Regulation of p21

Xinyi Yang,
Wei Wang,
Jiang-Jiang Qin,
Ming-Hai Wang,
Horrick Sharma,
John K. Buolamwini,
Hui Wang,
Ruiwen Zhang

Published: April 27, 2012
https://doi.org/10.1371/journal.pone.0034303

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