Spironolactone Lowers Portal Hypertension by Inhibiting Liver Fibrosis, ROCK-2 Activity and Activating NO/PKG Pathway in the Bile-Duct-Ligated Rat

Wei Luo; Ying Meng; Hong-Li Ji; Chun-Qiu Pan; Shan Huang; Chang-Hui Yu; Li-Ming Xiao; Kai Cui; Shu-Yuan Ni; Zhen-Shu Zhang; Xu Li

doi:10.1371/journal.pone.0034230

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Open Access

Peer-reviewed

Research Article

Spironolactone Lowers Portal Hypertension by Inhibiting Liver Fibrosis, ROCK-2 Activity and Activating NO/PKG Pathway in the Bile-Duct-Ligated Rat

Wei Luo ,

Contributed equally to this work with: Wei Luo, Ying Meng

Affiliation Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Southern Medical University, Nanfang Hospital, Guangzhou, China
⨯
Ying Meng ,

Contributed equally to this work with: Wei Luo, Ying Meng

Affiliation Department of Respiratory Diseases, Southern Medical University, Nanfang Hospital, Guangzhou, China
⨯
Hong-Li Ji,

Affiliation Department of Oncology, 153rd Hospital of People's Liberation Army, Zhengzhou, China
⨯
Chun-Qiu Pan,

Affiliation Department of Emergency, Southern Medical University, Nanfang Hospital, Guangzhou, China
⨯
Shan Huang,

Affiliation Department of Emergency, Southern Medical University, Nanfang Hospital, Guangzhou, China
⨯
Chang-Hui Yu,

Affiliation Department of Respiratory Diseases, Southern Medical University, Nanfang Hospital, Guangzhou, China
⨯
Li-Ming Xiao,

Affiliation Department of Emergency, Southern Medical University, Nanfang Hospital, Guangzhou, China
⨯
Kai Cui,

Affiliation Department of Cardiovascular, Southern Medical University, Nanfang Hospital, Guangzhou, China
⨯
Shu-Yuan Ni,

Affiliation Department of Emergency, Southern Medical University, Nanfang Hospital, Guangzhou, China
⨯
Zhen-Shu Zhang ,

* E-mail: zzs6689@163.com (ZSZ); mylx99@163.com (XL)

Affiliation Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Southern Medical University, Nanfang Hospital, Guangzhou, China
⨯
Xu Li

* E-mail: zzs6689@163.com (ZSZ); mylx99@163.com (XL)

Affiliation Department of Emergency, Southern Medical University, Nanfang Hospital, Guangzhou, China
⨯

Spironolactone Lowers Portal Hypertension by Inhibiting Liver Fibrosis, ROCK-2 Activity and Activating NO/PKG Pathway in the Bile-Duct-Ligated Rat

Wei Luo,
Ying Meng,
Hong-Li Ji,
Chun-Qiu Pan,
Shan Huang,
Chang-Hui Yu,
Li-Ming Xiao,
Kai Cui,
Shu-Yuan Ni,
Zhen-Shu Zhang

Published: March 30, 2012
https://doi.org/10.1371/journal.pone.0034230

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Aldosterone
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Portal hypertension
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