Puerarin Induces Mitochondria-Dependent Apoptosis in Hypoxic Human Pulmonary Arterial Smooth Muscle Cells

Chan Chen; Chun Chen; Zhiyi Wang; Liangxing Wang; Lehe Yang; Minjiao Ding; Cheng Ding; Yu Sun; Quan Lin; Xiaoying Huang; Xiaohong Du; Xiaowei Zhao; Chuangyi Wang

doi:10.1371/journal.pone.0034181

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Open Access

Peer-reviewed

Research Article

Puerarin Induces Mitochondria-Dependent Apoptosis in Hypoxic Human Pulmonary Arterial Smooth Muscle Cells

Chan Chen,

Affiliation Department of Geriatric Medicine, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang, China
⨯
Chun Chen,

Affiliation Department of Respiratory Medicine, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang, China
⨯
Zhiyi Wang,

Affiliation Department of Emergency Medicine, The Second Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang, China
⨯
Liangxing Wang ,

* E-mail: wzyxywlx@163.com

Affiliation Department of Respiratory Medicine, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang, China
⨯
Lehe Yang,

Affiliation Department of Respiratory Medicine, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang, China
⨯
Minjiao Ding,

Affiliation Department of Respiratory Medicine, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang, China
⨯
Cheng Ding,

Affiliation Department of Respiratory Medicine, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang, China
⨯
Yu Sun,

Affiliation Department of Respiratory Medicine, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang, China
⨯
Quan Lin,

Affiliation Department of Respiratory Medicine, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang, China
⨯
Xiaoying Huang,

Affiliation Department of Respiratory Medicine, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang, China
⨯
Xiaohong Du,

Affiliation Department of Geriatric Medicine, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang, China
⨯
Xiaowei Zhao,

Affiliation Department of Geriatric Medicine, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang, China
⨯
Chuangyi Wang

Affiliation Department of Geriatric Medicine, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang, China
⨯

Puerarin Induces Mitochondria-Dependent Apoptosis in Hypoxic Human Pulmonary Arterial Smooth Muscle Cells

Chan Chen,
Chun Chen,
Zhiyi Wang,
Liangxing Wang,
Lehe Yang,
Minjiao Ding,
Cheng Ding,
Yu Sun,
Quan Lin,
Xiaoying Huang

Published: March 23, 2012
https://doi.org/10.1371/journal.pone.0034181

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Apoptosis
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Medical hypoxia
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Mitochondria
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Hypoxia
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Outer membrane proteins
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Colorimetric assays
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Smooth muscle cells
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Pulmonary arteries
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