β-Cells with Relative Low HIMP1 Overexpression Levels in a Transgenic Mouse Line Enhance Basal Insulin Production and Hypoxia/Hypoglycemia Tolerance

Open Access

Peer-reviewed

Research Article

Xiaoping Zhang,

Affiliation Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America
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Linda Degenstein,

Affiliation Transgenic Core, The University of Chicago, Chicago, Illinois, United States of America
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Yun Cao,

Current address: Department of Medicine, Northwestern University, Chicago, Illinois, United States of America

Affiliation Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America
⨯
Jeffrey Stein,

Affiliation Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America
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Kwame Osei,

Affiliation Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America
⨯
Jie Wang

* E-mail: jie.wang2@osumc.edu

Affiliation Department of Internal Medicine, The Ohio State University, Columbus, Ohio, United States of America
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Heterozygosity
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Insulin
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Genetically modified animals
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Glucose
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Hyperexpression techniques
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Insulin secretion
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Blood sugar
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Hypoxia
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