Activation of Protein Kinase A and Exchange Protein Directly Activated by cAMP Promotes Adipocyte Differentiation of Human Mesenchymal Stem Cells

Bingbing Jia; Lise Madsen; Rasmus Koefoed Petersen; Nathalie Techer; Reidun Kopperud; Tao Ma; Stein Ove Døskeland; Gérard Ailhaud; Jinfu Wang; Ez-Zoubir Amri; Karsten Kristiansen

doi:10.1371/journal.pone.0034114

Loading metrics

Open Access

Peer-reviewed

Research Article

Activation of Protein Kinase A and Exchange Protein Directly Activated by cAMP Promotes Adipocyte Differentiation of Human Mesenchymal Stem Cells

Bingbing Jia,

Affiliations Institute of Cell Biology and Genetics, College of Life Sciences, Zhejiang University, Hangzhou, People's Republic of China, Department of Biology, University of Copenhagen, Copenhagen, Denmark
⨯
Lise Madsen,

Affiliations Department of Biology, University of Copenhagen, Copenhagen, Denmark, National Institute of Nutrition and Seafood Research, Bergen, Norway
⨯
Rasmus Koefoed Petersen,

Affiliation Department of Biology, University of Copenhagen, Copenhagen, Denmark
⨯
Nathalie Techer,

Affiliation IBV, Université de Nice Sophia-Antipolis, UMR7277 CNRS - UMR1091 INSERM, Faculté de Médecine, Nice, France
⨯
Reidun Kopperud,

Affiliation Department of Biomedicine, University of Bergen, Bergen, Norway
⨯
Tao Ma,

Affiliation Department of Biology, University of Copenhagen, Copenhagen, Denmark
⨯
Stein Ove Døskeland,

Affiliation Department of Biomedicine, University of Bergen, Bergen, Norway
⨯
Gérard Ailhaud,

Affiliation IBV, Université de Nice Sophia-Antipolis, UMR7277 CNRS - UMR1091 INSERM, Faculté de Médecine, Nice, France
⨯
Jinfu Wang ,

* E-mail: wjfu@zju.edu.cn (JW); kk@bio.ku.dk (KK)

Affiliation Institute of Cell Biology and Genetics, College of Life Sciences, Zhejiang University, Hangzhou, People's Republic of China
⨯
Ez-Zoubir Amri,

Affiliation IBV, Université de Nice Sophia-Antipolis, UMR7277 CNRS - UMR1091 INSERM, Faculté de Médecine, Nice, France
⨯
Karsten Kristiansen

* E-mail: wjfu@zju.edu.cn (JW); kk@bio.ku.dk (KK)

Affiliation Department of Biology, University of Copenhagen, Copenhagen, Denmark
⨯

Activation of Protein Kinase A and Exchange Protein Directly Activated by cAMP Promotes Adipocyte Differentiation of Human Mesenchymal Stem Cells

Bingbing Jia,
Lise Madsen,
Rasmus Koefoed Petersen,
Nathalie Techer,
Reidun Kopperud,
Tao Ma,
Stein Ove Døskeland,
Gérard Ailhaud,
Jinfu Wang,
Ez-Zoubir Amri

Published: March 27, 2012
https://doi.org/10.1371/journal.pone.0034114

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Adipocyte differentiation
Is the Subject Area "Adipocyte differentiation" applicable to this article?

Thanks for your feedback.
Insulin
Is the Subject Area "Insulin" applicable to this article?

Thanks for your feedback.
Adipocytes
Is the Subject Area "Adipocytes" applicable to this article?

Thanks for your feedback.
Fatty acids
Is the Subject Area "Fatty acids" applicable to this article?

Thanks for your feedback.
Cell staining
Is the Subject Area "Cell staining" applicable to this article?

Thanks for your feedback.
Adipose tissue
Is the Subject Area "Adipose tissue" applicable to this article?

Thanks for your feedback.
Mesenchymal stem cells
Is the Subject Area "Mesenchymal stem cells" applicable to this article?

Thanks for your feedback.
cAMP signaling cascade
Is the Subject Area "cAMP signaling cascade" applicable to this article?

Thanks for your feedback.